Institute of Experimental Medicine AS CR, v.v.i.

Granting Departments:	Department of Informatics and Chemistry Institute of Experimental Medicine AS CR, v.v.i.
Study Programme/Specialization:	Bioinformatics ( in English language )
Supervisor:	RNDr. Pavel Rössner, Ph.D.

Annotation

Environmental pollution represents a global problem affecting health of most of the population worldwide. To effectively protect the organism against negative impacts of environmental pollution detail molecular mechanisms of effects of pollutants need to be revealed. The aim of the thesis is to evaluate the impact of air pollution of whole-genome mRNA expression and epigenetic mechanisms (miRNA expression, DNA methylation) in model human cell systems in vitro. Lung and olfactory mucosa tissue models will be exposed to ambient air in localities with different levels of environmental pollution and mRNA expression profiles and epigenetic changes will be evaluated. The thesis should contribute to formulation of a detailed model describing, at molecular level, the response of the organism to ambient air pollutants.