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Obnovit | RAW
Department of Analytical Chemistry
Studies of conformational behavior of nucleic acids based on Raman spectroscopy and computations
Granting Departments: | Department of Analytical Chemistry |
Study Programme/Specialization: | Chemistry ( in Czech language ) |
Supervisor: | prof. RNDr. Petr Bouř, CSc. |
Annotation
Understanding of conformational behavior of biomolecules is important in biology and medicine. Raman optical activity is a modern spectroscopic method, very suitable for studies of the structure in water solutions. However, the interpretation of the spectra is dependent on their modeling using quantum-mechanics and molecular-dynamics simulations. This is difficult especially for large and complex molecules, such as nucleic acids. To advance the methodology, we will measure spectra of model polynucleotides and find the relation between spectral intensities and the structure and dynamics.
Contact supervisor
Study place:
Department of Analytical Chemistry, FCE, VŠCHT Praha
Updated: 17.2.2022 09:45, Author: Jan Kříž