Institute of Organic Chemistry and Biochemistry of the CAS

Study place:	Institute of Organic Chemistry and Biochemistry of the CAS
Guaranteeing Departments:	Department of Chemistry of Natural Compounds Institute of Organic Chemistry and Biochemistry of the CAS
Study Programme/Specialization:
Also available in study programmes:	Biochemistry and Bioorganic Chemistry ( in English language ), Chemistry ( in English language )
Supervisor:	Dr. habil. Ullrich Jahn
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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The axinellamines belong to the most complex alkaloids with interesting biological properties. With this project biomimetic approaches will be explored to enable short total syntheses of the natural products themselves and of analogs. Their biological profile will be investigated in collaboration.

Study place:	Institute of Organic Chemistry and Biochemistry of the CAS
Guaranteeing Departments:	Department of Organic Chemistry Institute of Organic Chemistry and Biochemistry of the CAS
Study Programme/Specialization:	Chemistry ( in English language )
Supervisor:	Dr. Paulo Paioti
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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We recently developed a method for synthesis of otherwise difficult-to-access atropisomers by nucleophilic aromatic substitution. One advantage is that starting materials, N‒H heterocycles and fluoroarenes, are readily available, and another is that the reactions are highly efficient and broadly applicable. However, the method currently produces racemates of atropisomers and is not catalytic. Accordingly, PhD students in our laboratory will develop catalytic atroposelective synthesis of such compounds and others. Several possibilities will be studied. The molecules synthesized in this project will be tested broadly in medicinal chemistry screenings.

Study place:	Institute of Organic Chemistry and Biochemistry of the CAS
Guaranteeing Departments:	Department of Informatics and Chemistry Institute of Organic Chemistry and Biochemistry of the CAS
Study Programme/Specialization:	Bioinformatics ( in English language )
Supervisor:	Mgr. Tomáš Pluskal, Ph.D.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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Our lab combines experimental (mass spectrometry, metabolomics and RNA-seq) and computational (bioinformatics and machine learning) approaches for the discovery of novel bioactive molecules derived from plants. The aim of this project will be the development of new computational methods for processing and interpreting small molecule mass spectrometry data, in particular for automated mass spectra interpretation, molecule annotation, and generation and visualization of molecular networks. Candidates for this position should be able to independently program in Java and Python.

Study place:	Institute of Organic Chemistry and Biochemistry of the CAS
Guaranteeing Departments:	Department of Biochemistry and Microbiology Institute of Organic Chemistry and Biochemistry of the CAS
Study Programme/Specialization:	Biochemistry and Bioorganic Chemistry ( in English language )
Supervisor:	Mgr. Tomáš Kouba, Ph.D.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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Effective treatment against influenza viruses (Flu) suffers from virus resistance. Therefore, there is a great demand for exploring new drug targets and developing effective novel antivirals. This is challenging, since there is only a limited number of antiviral targets for rational drug design. This project will tackle both; it will explore and verify a new target and develop inhibitors against it. Cutting edge results in structural biology of the influenza RNA-dependent RNA polymerase (FluPol), identified a common general mechanism of Flu RNA transcription and replication cycle. The mechanism is entirely dependent on binding of viral endogenous RNA molecules to specific sites on the FluPol. Aided by already existing cryo-EM structures of FluPol, we will design inhibitors based on the sequence, atomic structure and interactions with the protein, and add extensive chemical modification to these viral RNAs. We will then test whether they can inhibit FluPol by in vitro and in cell-based experiments. Targeting these RNA binding sites and using RNA-scaffold based molecules is an innovative concept and expected to be robust in respect to the development of viral resistance. Altogether, the approach has great potential to bring a new universal paradigm to the field of antiviral drug discovery.

Study place:	Institute of Organic Chemistry and Biochemistry of the CAS
Guaranteeing Departments:	Department of Organic Chemistry Institute of Organic Chemistry and Biochemistry of the CAS
Study Programme/Specialization:
Also available in study programmes:	Drugs and Biomaterials ( in English language ), Biochemistry and Bioorganic Chemistry ( in English language )
Supervisor:	Mgr. Radim Nencka, Ph.D.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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The Ph.D. student will design and synthesise novel methyltransferase (MTase) inhibitors targeting viral, fungal or human MTases. The student will use in silico approach to speed up the development of potential drugs, but the main part of the assignment will be the organic synthesis. Preparation of suitable ligands bearing a fluorescent tag will enable the efficient development of a screening assay.

Study place:	Institute of Organic Chemistry and Biochemistry of the CAS
Guaranteeing Departments:	Department of Organic Chemistry Institute of Organic Chemistry and Biochemistry of the CAS
Study Programme/Specialization:	Chemistry ( in English language )
Supervisor:	RNDr. Tomáš Slanina, Ph.D.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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Photoinduced electron transfer and charge separation is one of the most important phenomena in Universe. It plays an important role in processes essential for life, such as photosynthesis, respiration, protein folding and biocatalysis. It is also highly relevant for solar cells, batteries, molecular electronics and smart materials. The thesis will focus on development of systems for reversible charge transfer between two redox-active centres. The transfer of charge will be in both directions controlled by photoinduced electron transfer and both states will be stabilized by follow-up chemical reaction (intramolecular cyclization, protonation and others). Reversible photoinduced electron transfer will be used for dipole reorientation, control of charges and counterions and regulation of electrostatic interactions. These unique properties will be further used in design of novel materials and devices in molecular electronics. The candidate will perform synthesis and characterization of organic redox-active molecules and will study their properties. Highly motivated and skilful candidate will have the opportunity to extend his/her graduate training in physical and organic chemistry by learning electrochemical, photochemical and advanced spectroscopic methods.

Study place:	Institute of Organic Chemistry and Biochemistry of the CAS
Guaranteeing Departments:	Department of Chemistry of Natural Compounds Institute of Organic Chemistry and Biochemistry of the CAS
Study Programme/Specialization:	Biochemistry and Bioorganic Chemistry ( in English language )
Supervisor:	Mgr. Tomáš Pluskal, Ph.D.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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Our lab combines cutting-edge experimental (e.g., LC-MS, metabolomics, RNA-seq) and computational (e.g., bioinformatics, molecular networking, machine learning) approaches to develop new workflows for the discovery and utilization of bioactive molecules derived from plants. This project will focus on screening many plant species using liquid chromatography mass spectrometry to discover and isolate unique chemicals (metabolites), including basic characterization of their bioactive potential.

Study place:	Institute of Organic Chemistry and Biochemistry of the CAS
Guaranteeing Departments:	Department of Organic Chemistry Institute of Organic Chemistry and Biochemistry of the CAS
Study Programme/Specialization:	Chemistry ( in English language )
Supervisor:	prof. Ing. Michal Hocek, DSc.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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Nucleotides bearing specific ligands or reactive groups will be designed and synthesized, from which modified DNA will be synthesized by enzyme methods and used to attach target proteins. Applications will include multi-enzyme systems.

Study place:	Institute of Organic Chemistry and Biochemistry of the CAS
Guaranteeing Departments:	Department of Biochemistry and Microbiology Institute of Organic Chemistry and Biochemistry of the CAS
Study Programme/Specialization:	Biochemistry and Bioorganic Chemistry ( in English language )
Supervisor:	prof. Ing. Michal Hocek, DSc.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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Nucleotides bearing specific ligands or reactive groups will be designed and synthesized, from which modified DNA will be synthesized by enzyme methods and used to attach target proteins. Applications will include multi-enzyme systems.

Study place:	Institute of Organic Chemistry and Biochemistry of the CAS
Guaranteeing Departments:	Department of Organic Chemistry Institute of Organic Chemistry and Biochemistry of the CAS
Study Programme/Specialization:
Also available in study programmes:	Chemistry ( in English language ), Biochemistry and Bioorganic Chemistry ( in English language )
Supervisor:	prof. Ing. Michal Hocek, DSc.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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Modified 2'-deoxyribonucleoside-triphosphates will be synthesized and used in enzymatic synthesis of oligodeoxyribonucleotides and DNA bearing several modifications at specific positions using a novel approach involving repeated annealing of RNA templates, primer extension and RNA digestion. Applications will include the spatially defined attachment of several different biomolecules, particularly proteins, to DNA.

Study place:	Institute of Organic Chemistry and Biochemistry of the CAS
Guaranteeing Departments:	Department of Biochemistry and Microbiology Institute of Organic Chemistry and Biochemistry of the CAS
Study Programme/Specialization:	Biochemistry and Bioorganic Chemistry ( in English language )
Supervisor:	Ing. Iva Pichová, CSc.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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Terpenoid secondary metabolites are used by organisms for communication and defense, and their biological activities are exploited by industries such as pharmaceuticals, cosmetics, or food and flavour. This PhD project addresses the question of evolutionary origin of terpenoid biosynthesis in insects. Terpene synthases (TPS) are key enzymes responsible for the conversion of prenyl pyrophosphates into terpenes, and insect TPSs are unrelated to their plant or microbial counterparts. They have evolved multiple times independently in different insect lineages. Our understanding remains limited in terms of their reaction mechanisms and structure-activity relationships. Within this PhD project, the doctoral candidate will functionally characterize a set of insect terpene synthases from unrelated insect clades and define their common and idiosyncratic structural features acquired during their multiple independent origins. This PhD project is funded by the European MSCA Doctoral Network ‘ModBioTerp’ and the grant support for the broader research project is funded by Ministry of Education, Youth, and Sports (2024-2027).

Study place:	Institute of Organic Chemistry and Biochemistry of the CAS
Guaranteeing Departments:	Department of Chemistry of Natural Compounds Institute of Organic Chemistry and Biochemistry of the CAS
Study Programme/Specialization:	Biochemistry and Bioorganic Chemistry ( in English language )
Supervisor:	Dr. habil. Ullrich Jahn
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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We just accomplished approaches to glycine alkoxyamines, which hold large promise in bioconjugation. With this project the potential of these non-natural amino acid derivatives for approaching new peptide architectures will be explored.

Study place:	Institute of Organic Chemistry and Biochemistry of the CAS
Guaranteeing Departments:	Department of Organic Chemistry Institute of Organic Chemistry and Biochemistry of the CAS
Study Programme/Specialization:	Chemistry ( in English language )
Supervisor:	Dr. habil. Ullrich Jahn
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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We just accomplished approaches to glycine alkoxyamines, which hold large promise in bioconjugation. With this project the potential of these non-natural amino acid derivatives for approaching new peptide architectures will be explored.

Study place:	Institute of Organic Chemistry and Biochemistry of the CAS
Guaranteeing Departments:	Institute of Organic Chemistry and Biochemistry of the CAS
Study Programme/Specialization:
Also available in study programmes:	Chemistry ( in English language ), Chemistry ( in English language )
Supervisor:	RNDr. Ivo Starý, CSc.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship + salary
Other expected Forms of Study / Methods of Funding:
Full-time / Scholarship ( in study programme - Chemistry ( in English language ) )

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The goal of the PhD project will be the development of new helically chiral metal complexes to be explored in enantioselective catalysis. The attention will be paid to the synthesis of cyclometallated helicenes and helical cyclopentadienyl complexes. They will be applied to selected enantioselective reactions catalysed by transition metals such as alkyne cycloisomerisation, olefin metathesis or hydrogenation.

Study place:	Institute of Organic Chemistry and Biochemistry of the CAS
Guaranteeing Departments:	Department of Organic Chemistry Institute of Organic Chemistry and Biochemistry of the CAS
Study Programme/Specialization:
Also available in study programmes:	Drugs and Biomaterials ( in English language ), Biochemistry and Bioorganic Chemistry ( in English language )
Supervisor:	Mgr. Radim Nencka, Ph.D.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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The PhD student will focus on the design and organic synthesis of new methyltransferase inhibitors, whether derived from viral, fungal, or human sources. In the course of developing these compounds, the candidate will employ in silico molecular modeling to streamline and accelerate the search and optimization of inhibitors. Nonetheless, the main emphasis of the project will remain on the organic synthesis of potential therapeutic agents. Additionally, the project will include the preparation of ligand analogs equipped with suitable tags, whether fluorescent or functional (e.g., biotin for pull-down assays, thalidomide for PROTAC technology).

Study place:	Institute of Organic Chemistry and Biochemistry of the CAS
Guaranteeing Departments:	Institute of Organic Chemistry and Biochemistry of the CAS
Study Programme/Specialization:	Chemistry ( in English language )
Supervisor:	RNDr. Ota Bludský, CSc.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship + salary

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This thesis aims to enhance our understanding of how the dynamic behaviors of host-guest systems in porous solids affect mass transport properties, which are crucial for adsorption and catalysis. It focuses on three key issues: (i) the role of composition and guest molecules in the mass transport properties of flexible materials such as zeolites and ZIFs, (ii) gating effects in low-silica materials, and (iii) the influence of internal defects (e.g., silanols) on gas separation.

Study place:	Institute of Organic Chemistry and Biochemistry of the CAS
Guaranteeing Departments:	Department of Chemistry of Natural Compounds Institute of Organic Chemistry and Biochemistry of the CAS
Study Programme/Specialization:	Biochemistry and Bioorganic Chemistry ( in English language )
Supervisor:	Mgr. Tomáš Pluskal, Ph.D.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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Our lab combines cutting-edge experimental (e.g., LC-MS, metabolomics, RNA-seq) and computational (e.g., bioinformatics, molecular networking, machine learning) approaches to develop new workflows for the discovery and utilization of bioactive molecules derived from plants. The aim of this project will be to engineer new microbial platforms for the bioproduction of terpenoid precursors and terpenoids derived from them.

Study place:	Institute of Organic Chemistry and Biochemistry of the CAS
Guaranteeing Departments:	Department of Informatics and Chemistry Institute of Organic Chemistry and Biochemistry of the CAS
Study Programme/Specialization:	Bioinformatics ( in English language )
Supervisor:	Mgr. Tomáš Pluskal, Ph.D.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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The goal of this project is to enable computational characterization and engineering of terpene synthases, an important class of biosynthetic enzymes responsible for creating the chemical scaffolds of the largest class of natural products, terpenoids. The project has three objectives: 1. Assembly of a comprehensive database describing the reaction mechanisms of terpene synthases characterized to date. 2. Development of a deep learning model using transformer neural networks for predicting the substrates, products, and reaction mechanisms of terpene synthases directly from their amino acid sequences. 3. Development of a generative algorithm for designing artificial terpene synthases with a desired function.

Study place:	Institute of Organic Chemistry and Biochemistry of the CAS
Guaranteeing Departments:	Department of Organic Chemistry Institute of Organic Chemistry and Biochemistry of the CAS
Study Programme/Specialization:	Chemistry ( in English language )
Supervisor:	Mgr. Jiří Kaleta, Ph.D.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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The project focuses on the development and study of special light-switchable organic molecules that mimic the function of biological systems. These synthetic "molecular machines" will be composed of various photoswitches and molecular motors, with their individual components selectively switched or activated using light of specific wavelengths. The primary goal of the Ph.D. project is the preparation and detailed investigation of these unique molecules and their potential application in the construction of functional prototypes of molecular machines. Emphasis will be placed on different combinations of photoswitches and the methods of their interconnection (orthogonal vs. non-orthogonal).

Study place:	Institute of Organic Chemistry and Biochemistry of the CAS
Guaranteeing Departments:	Department of Organic Chemistry Institute of Organic Chemistry and Biochemistry of the CAS
Study Programme/Specialization:	Chemistry ( in English language )
Supervisor:	Ing. Zlatko Janeba, Ph.D.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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In medicinal chemistry, heterocyclic moieties represent important pharmacophores of various biologically active compounds. The goal of this project will be synthesis and structural optimization of novel heterocyclic compounds with potential anticancer properties, and evaluation of their biological properties (activity, ADME, etc.).

Study place:	Institute of Organic Chemistry and Biochemistry of the CAS
Guaranteeing Departments:	Institute of Organic Chemistry and Biochemistry of the CAS
Study Programme/Specialization:	Molecular chemical physics and sensorics ( in English language )
Supervisor:	Mgr. Petr Cígler, Ph.D.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship + salary

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Photoluminescent nanodiamonds represent a novel type of quantum biosensor that exploits changes in luminescent properties in response to external stimuli. Compared to classical sensors, they offer the benefits of high sensitivity and resolution but are often nonspecific. The aim of the project is to chemically functionalize these sensors for specific and sensitive detection in biologically relevant environments. To achieve this, the student will employ covalent surface modifications of nanosensors in a colloidal state and subsequently characterize them. The functionality of the constructed nanosensors will be verified using a quantum confocal microscope with advanced pulse sequences. The outcome of the project will be time-resolved, localized quantum detection of specific molecules.

Study place:	Institute of Organic Chemistry and Biochemistry of the CAS
Guaranteeing Departments:	Institute of Organic Chemistry and Biochemistry of the CAS
Study Programme/Specialization:	Molecular chemical physics and sensorics ( in English language )
Supervisor:	Mgr. Petr Cígler, Ph.D.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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Quantum nanosensors offer significant advantages over classical sensors, including high sensitivity and resolution. One type of such quantum nanosensor is photoluminescent nanoparticles, whose detection is based on monitoring luminescence changes in response to external stimuli. The goal of the project is to read optical nanosensors using pulsed optical EPR detection and tracking spectral changes. The student will design and implement advanced pulse sequences into an existing quantum confocal microscope, conduct measurements, and analyze the results. Furthermore, they will optimize the sensitivity of the nanosensors through chemical surface modifications. The outcome of the project will be time-resolved, localized quantum detection in biologically relevant environments.

Study place:	Institute of Organic Chemistry and Biochemistry of the CAS
Guaranteeing Departments:	Department of Biochemistry and Microbiology Institute of Organic Chemistry and Biochemistry of the CAS
Study Programme/Specialization:	Biochemistry and Bioorganic Chemistry ( in English language )
Supervisor:	David Marcelo Sabatini, M.D., Ph.D.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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My lab has a long-standing interest in the regulation of growth and metabolism. This interest stems from our early work on the pathway anchored by mTOR protein kinase, which we now appreciate is a major regulator of growth and anabolism responds to nutrients. Because we found that lysosomes play a key role in the activation of mTORC1 by nutrients, we began to study lysosomes as well as other organelles, like mitochondria. We developed methods for the rapid isolation and profiling of these organelles (e.g., Lyso-IP), and used them to deorphan the functions of disease-associated genes. Because mTORC1 senses nutrients, we also became interested in the metabolic pathways that cells to use incorporate biomass and generate energy. (1) Nutrient sensing by mTORC1 in vitro and in vivo. We seek to identify the glucose sensor for the mTORC1 pathway; discover nutrient sensors in animals beyond mammals; understand how the nutrient sensors function in vivo. (2) Lysosomes in normal physiology and disease.We seek to understand how common and rare neurodegenerative diseases impact lysosomal function and identify the contents of lysosomes in specialized cells. (3) In collaboration with chemists, we will develop drug-like molecules that target mTOR pathway components as well lysosomal proteins.

Study place:	Institute of Organic Chemistry and Biochemistry of the CAS
Guaranteeing Departments:	Institute of Organic Chemistry and Biochemistry of the CAS
Study Programme/Specialization:	Molecular chemical physics and sensorics ( in English language )
Supervisor:	Doc. Mgr. Michal Straka, Ph.D.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship + salary

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With the miniaturization of electronic components nearing its limits, single-molecule components hold great potential as a solution. Our proposal aims to address a gap in molecular electronics by developing switchable spin-filters. We will begin with an in-depth in silico survey to identify experimentally viable molecules, with a focus on introducing spin-filtering via open-shell metal atoms, chirality, or both. Our initial targets include metalloporphyrins, helicenes, short peptides, and endohedral fullerenes. By combining spin-filtering with field-induced spin crossover and isomerization, we can control the transmission properties of these molecules. We will construct a library of in silico characterized systems and use electronic structure to gain a fundamental understanding of their function. The best compounds will be synthesized and characterized experimentally to guide further experiments and provide feedback for our rational design. Ultimately, we envision applications in data storage and in-memory computing.

Study place:	Institute of Organic Chemistry and Biochemistry of the CAS
Guaranteeing Departments:	Department of Organic Chemistry Institute of Organic Chemistry and Biochemistry of the CAS
Study Programme/Specialization:	Chemistry ( in English language )
Supervisor:	Mgr. Tomáš Pluskal, Ph.D.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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Our lab combines cutting-edge experimental (e.g., LC-MS, metabolomics, RNA-seq) and computational (e.g., bioinformatics, molecular networking, machine learning) approaches to develop new workflows for the discovery and utilization of bioactive molecules derived from plants. The aim of this project will be the development of methods for structural analysis of small molecules isolated from plants using the technique of crystalline sponge X-ray diffraction. The applicants for this position should already have laboratory experience with small molecule crystallography.

Study place:	Institute of Organic Chemistry and Biochemistry of the CAS
Guaranteeing Departments:	Department of Organic Chemistry Institute of Organic Chemistry and Biochemistry of the CAS
Study Programme/Specialization:	Chemistry ( in English language )
Supervisor:	RNDr. Tomáš Slanina, Ph.D.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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Electrophiles and Lewis acids are among the most common intermediates utilized for catalytic reactions. Many attempts have been made to characterize and classify the strength and reactivity of these electron deficient species. However, the classical concept of electrophilicity and Lewis acidity starts to fall apart when open-shell (radicals, radical ions) and excited states are considered. The thesis will focus on development of electrophilic systems with open-shell and electronically excited electronic structure capable of various non-classical interactions with nucleophilic and radical partners. This unique behaviour will not only be applied in novel catalytic reactions but if will be used in re-formulation of rules for chemical bonding between open-shell and electronically excited species. The candidate will perform synthesis and characterization of organic non-classical electrophiles and Lewis acids and will study their catalytic properties and non-covalent interactions. Highly motivated and skilful candidate will have the opportunity to extend his/her graduate training in organic chemistry by learning electrochemical, photochemical and physicochemical methods.

Study place:	Institute of Organic Chemistry and Biochemistry of the CAS
Guaranteeing Departments:	Department of Organic Chemistry Institute of Organic Chemistry and Biochemistry of the CAS
Study Programme/Specialization:
Also available in study programmes:	Chemistry ( in English language ), Chemistry ( in English language )
Supervisor:	RNDr. Ivo Starý, CSc.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship
Other expected Forms of Study / Methods of Funding:
Full-time / Scholarship + salary ( in study programme - Chemistry ( in English language ) )

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The aim of the project is to prepare new helical TADF and excimer luminophores derived from helicenes and to study their chiroptical properties in solution and thin films (in particular circularly polarized luminescence) in order to identify suitable materials for future CP-OLED design.

Study place:	Institute of Organic Chemistry and Biochemistry of the CAS
Guaranteeing Departments:	Department of Organic Chemistry Institute of Organic Chemistry and Biochemistry of the CAS
Study Programme/Specialization:	Chemistry ( in English language )
Supervisor:	Ing. Zlatko Janeba, Ph.D.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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The goal of the project will be synthesis and structural optimization of novel antiviral compounds, and evaluation of their biological as well as pharmacokinetic properties (in collaboration with other scientific groups as virology and biochemical pharmacology). Suitable prodrugs will be prepared and studied, if necessary.

Study place:	Institute of Organic Chemistry and Biochemistry of the CAS
Guaranteeing Departments:	Department of Organic Chemistry Institute of Organic Chemistry and Biochemistry of the CAS
Study Programme/Specialization:	Chemistry ( in English language )
Supervisor:	Dr. habil. Ullrich Jahn
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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With the project, synthetic approaches to complex indoloterpene and their analogs displaying wide-ranging biological activity will be developed.

Study place:	Institute of Organic Chemistry and Biochemistry of the CAS
Guaranteeing Departments:	Department of Chemistry of Natural Compounds Institute of Organic Chemistry and Biochemistry of the CAS
Study Programme/Specialization:	Biochemistry and Bioorganic Chemistry ( in English language )
Supervisor:	Dr. habil. Ullrich Jahn
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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With the project, synthetic approaches to complex indoloterpene and their analogs displaying wide-ranging biological activity will be developed.

Study place:	Institute of Organic Chemistry and Biochemistry of the CAS
Guaranteeing Departments:	Department of Organic Chemistry Institute of Organic Chemistry and Biochemistry of the CAS
Study Programme/Specialization:
Also available in study programmes:	Chemistry ( in English language ), Chemistry ( in English language )
Supervisor:	RNDr. Irena G. Stará, CSc.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship

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The aim of the project is to develop the synthesis of new warped and chiral nanocarbons such as helical pi-conjugated macrocycles, circulenes and cycloarenes. The chiral substances will be prepared in optically pure form by resolution of racemates or by asymmetric synthesis. Their (chir)optical properties, self-assembly in 2D/3D space, aromatic character and their conformational or redox behaviour will be studied in order to identify their possible applications in chemistry or nanoscience.