Department of Chemistry of Natural Compounds

Study place:	Department of Chemistry of Natural Compounds, FFBT, VŠCHT Praha
Guaranteeing Departments:	Department of Chemistry of Natural Compounds
Study Programme/Specialization:	Biochemistry and Bioorganic Chemistry ( in English language )
Supervisor:	doc. Ing. Kamil Parkan, Ph.D.
Expected Form of Study:	Full-time
Expected Method of Funding:	Scholarship + salary

Annotation

Carbohydrates are essential biomolecules that play a crucial role in various biological processes, such as cell signaling, adhesion, recognition, and intercellular communication. In the context of biomedicine, carbohydrates and their derivatives represent important targets for the development of new therapeutic agents. Glycomimetics are synthetic analogs of carbohydrates that mimic their biological functions; however, unlike natural carbohydrates, they are stable against chemical and enzymatic hydrolysis, enhancing their therapeutic potential and applicability. The aim of this doctoral project is to design, synthesize, and characterize new glycomimetic structures with potential applications in targeted therapy and diagnostics. The focus will be on developing compounds with high specificity and affinity for receptors involved in pathological processes, such as inflammation, infections, and tumor growth. The final glycomimetics will undergo biological testing to evaluate their therapeutic and diagnostic potential. This topic is primarily intended for graduates of chemistry or pharmaceutical fields. Throughout the project, the student will acquire in-depth knowledge of organic synthesis, separation and purification techniques, and modern structural analysis methods (NMR, MS, HPLC). The project will also include basic biological evaluation of the synthesized compounds.