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Biotechnology
Doctoral Programme,
Faculty of Food and Biochemical Technology
The purpose of the study programme is to train specialists in biotechnology and other related fields. The study focuses on scientific research and its applications in the development of new products and technologies using the biological agent as the basis of the process. Special attention is paid to the specific properties of microbial, plant, and animal cells and to the acquisition of the ability to apply this knowledge in the development of new products. An integral part is the development of new technical (engineering) solutions to biotechnological processes. The study is therefore focused on a comprehensive studying of theoretical knowledge in chemical, biological, engineering and economic sciences, and on gaining practical experience and skills in the field of management and methodology of biotechnological research. Graduates of this programme can participate in basic and applied research at academic institutions and universities, but they can also participate in practice in the Czech Republic and abroad. CareersThe graduates of the doctoral study programme Biotechnology are engaged in scientific research focused primarily on the development and optimization of processes for the production of pharmaceutical products, pure chemicals, biofuels, as well as traditional fermentation products. Other applications are directly in the biotechnology industry and related areas of the food, pharmaceutical and chemical industries, including in the area of bio-waste processing and environmental protection. They can hold managerial positions in development, production, control and design in commercial institutions and state administration bodies. Due to the wide concept of expertise they are prepared not only for professional work in their specialization, but also for easy adaptation to possible work in other technological and natural sciences fields. This DSP fully reflects employers' requirements for university graduates, including language skills. Employers prefer broad, interdisciplinary professional skills for future employees as well as key competencies - so-called “soft knowledge and skills”. Programme Details
Ph.D. topics for study year 2026/27Possibilities of influencing the production of secondary metabolites by the fungus <i>Monascus pilosus</i> and the food use of this species
AnnotationMonascus pilosus is a lesser-known species of fungus of the genus Monascus, which is primarily known as a producer of monacolin K. However, the essence of the work will be to study the biosynthesis of polyketide pigments in this species and the possibility of influencing their production not only by cultivation conditions (composition of the culture medium, type of cultivation), but also by other interventions (random mutagenesis, addition of epigenetic regulators). Pigment production will be evaluated not only using chromatographic techniques, but also using the RT-qPCR method. The work will include the separation of the most abundant pigments (e.g., monascuspiloin) using a combination of extraction with various solvents and sorption/elution in suitable materials. The isolated pigments will be used to test antimicrobial properties. The work will also evaluate the potential for food use of this species, which does not produce the mycotoxin citrinin (preparation of fermented foods, use of enzyme and pigment production in the food industry). |
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Updated: 20.1.2022 16:26, Author: Jan Kříž