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Drugs and Biomaterials
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Programme Details
| Study Language
|
Czech |
|
Standard study length
|
4 years |
| Form of study
|
combined
,
full-time
|
| Guarantor
|
prof. Ing. Radek Cibulka, Ph.D.
|
| Place of study
|
Praha |
| Capacity
|
30 students |
| Programme code (national)
|
P0531D130072 |
| Programme Code (internal)
|
D105
|
| Number of Ph.D. topics
|
5 |
Ph.D. topics for study year 2026/27
Analysis of blood-based derivatives for the diagnosis of serious diseases of gastrointestinal tract
|
Study place:
|
Department of Analytical Chemistry, FCE, VŠCHT Praha
|
| Guaranteeing Departments: |
Department of Analytical Chemistry
|
|
Also available in study programmes:
|
Chemistry (
in Czech language
)
|
| Supervisor: |
prof. Ing. Vladimír Setnička, Ph.D.
|
| Expected Form of Study: |
Full-time |
| Expected Method of Funding: |
Scholarship |
Annotation
Mezi závažná onemocnění trávicí soustavy patří například karcinomy jater, jícnu, žaludku, slinivky, střev a konečníku. Časná diagnostika mnohých z nich je však v současné době velmi omezená a konvenční klinické přístupy nedosahují požadované spolehlivosti. Tato práce se zaměřuje na hledání nových cest využívajících pokročilé spektroskopické metody (především vibrační a chiroptické spektroskopie) při analýze krevních derivátů (typicky krevní plazmy z tekuté biopsie) pacientů a kontrolních jedinců pro identifikaci nových diagnostických markerů těchto onemocnění. Spektroskopické, případně omické, přístupy jsou navíc velmi šetrné pro pacienta. Práce bude realizována ve spolupráci se špičkovými klinickými pracovišti pražských fakultních nemocnic.
Tissue analysis using vibrational spectroscopy methods for the diagnosis of cancer diseases
|
Study place:
|
Department of Analytical Chemistry, FCE, VŠCHT Praha
|
| Guaranteeing Departments: |
Department of Analytical Chemistry
|
| Supervisor: |
prof. Ing. Vladimír Setnička, Ph.D.
|
| Expected Form of Study: |
Full-time |
| Expected Method of Funding: |
Scholarship |
Annotation
Metody vibrační spektroskopie (především Ramanova a infračervená) patří mezi účinné nástroje strukturní analýzy a stále častěji je studován jejich potenciál v oblasti klinické diagnostiky některých závažných onemocnění (nádorových či neurodegenerativních). Předmětem této disertační práce bude vývoj instrumentace a algoritmů umožňujících chemickou analýzu tkání s cílem nalézt spolehlivé spektrální markery pro diagnostiku některých závažných onemocnění, například karcinomu tlustého střeva či karcinomu plic. V součinnosti s klinickými pracovišti (např. Všeobecnou fakultní nemocnicí Praha) budou testovány unikátní Ramanovy mikrosondy, které by umožnily in vivo analýzu tkáňových vzorků bez nutnosti jejich odběru. Rovněž budou analyzovány tkáňové vzorky z biopsií.
Particle informatics
|
Study place:
|
Department of Chemical Engineering, FCE, VŠCHT Praha
|
| Guaranteeing Departments: |
Department of Chemical Engineering
|
|
Also available in study programmes:
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Drugs and Biomaterials (FCE) (
in English language
)
|
| Supervisor: |
prof. Ing. Miroslav Šoóš, Ph.D.
|
| Expected Form of Study: |
Full-time |
| Expected Method of Funding: |
Scholarship + salary |
Annotation
Drug substances are typically produced in the form of crystals. However, the properties of these crystals can vary dramatically when considering various polymorphs or multicomponent drug solid forms (i.e., salts or cocrystals). The goal of this project is to characterize the surface properties of the drug crystals utilizing the crystal structure. As a part of the project, the student will be involved in the preparation of drug solid forms of interest and their characterization using single-crystal XRD, followed by the solution of the crystal structure. The obtained information will be used to predict properties of the crystal surface in terms of molecules present on the surface, hydrophobicity/hydrophilicity of the surface, intermolecular interactions between molecules located on the crystal surface and to correlate these data with the properties of produced crystals (e.g., stability under elevated temperature or humidity, solubility or dissolution). Furthermore, we would extend the information about the crystal structure to the prediction of crystal-crystal interaction and their relation to the crystal flowability or prediction of bulk properties of crystals (e.g., hardness) and its relation to powder tabletability
Structural studies and identification of pharmaceutically important and psychoactive substances using vibrational and chiroptical spectroscopy
|
Study place:
|
Department of Analytical Chemistry, FCE, VŠCHT Praha
|
| Guaranteeing Departments: |
Department of Analytical Chemistry
|
|
Also available in study programmes:
|
Chemistry (
in Czech language
)
|
| Supervisor: |
prof. Ing. Vladimír Setnička, Ph.D.
|
| Expected Form of Study: |
Full-time |
| Expected Method of Funding: |
Scholarship |
Annotation
Práce je zaměřena na vývoj metod strukturní analýzy farmaceuticky významných a psychoaktivních molekul a nových nástrojů pro odhalování drog a padělků léčiv s využitím metod vibrační (infračervené a Ramanovy) a chiroptické (cirkulární dichroismus, Ramanova optická aktivita) spektroskopie. Student bude analyzovat nejen čisté látky (mnohdy chirální povahy), ale též reálné vzorky ze záchytů, především z oblasti anabolických steroidů, disociativních anestetik a syntetických drog. Budou též sledovány specifické projevy přítomnosti chirálních nečistot a matric. Analýza struktury a interpretace spekter bude podpořena metodami molekulárního modelování. Práce bude realizována ve spolupráci s Kriminalistickým ústavem Policie České republiky a za podpory grantových projektů Ministerstva vnitra ČR.
Utilization of inter-and intra-molecular interactions in modelling of drug-polymer systems
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Study place:
|
Department of Chemical Engineering, FCE, VŠCHT Praha
|
| Guaranteeing Departments: |
Department of Chemical Engineering
|
|
Also available in study programmes:
|
Drugs and Biomaterials (FCE) (
in English language
)
|
| Supervisor: |
prof. Ing. Miroslav Šoóš, Ph.D.
|
| Expected Form of Study: |
Full-time |
| Expected Method of Funding: |
Scholarship + salary |
Annotation
Interparticle interactions play a significant role during the process of micelle formation, stabilization of nanoparticles during antisolvent precipitation, stabilization of drug molecules in supersaturated solution during drug dissolution, or even in the process of selection of suitable polymers to prepare amorphous solid dispersion. In this thesis, we would like to utilize quantum mechanics and all-atom molecular dynamic simulations to tackle the above-mentioned challenges. The first studied system will contain a selection of suitable polymers to prepare an amorphous solid solution (ASS) with the selected drug while maximizing the long-term stability of ASS. In addition, we plan to study the interaction of selected polymers with a drug in a water environment to maximize drug solubility and prevent drug precipitation from supersaturated solution. The second studied system will consist of surfactant molecules (both synthetic and natural) in a water environment where we plan to study the impact of concentration of surfactant molecules, length of hydrophobic and hydrophilic chains, presence of ionic strength or temperature variation on the formation of micelles/surfactant molecule coils. Particular attention will be considered when drugs are added to this system, where the goal will be to understand the solubilization of drug molecules in the surfactant micelles. Obtained results will be compared with available experimental data containing the solubility of the drug in a polymer, time evolution of drug concentration in the supersaturated solution stabilized with polymer, or permeation measurement of drug molecules in the presence of surfactants and polymers. Simulations will start from quantum-chemical calculations of the COSMO-RS type to enable the first and relatively quick qualitative estimation of Hansen's solubility parameters and can thus serve in the initial screening of suitable polymers. In the next step, molecular dynamic simulations will be used to simulate the polymer-drug affinity in a real system arrangement (ideally including basic experimental knowledge).
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