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Programme Details
Ph.D. topics for study year 2026/27Applications of optically active spiropyran photoswitches in smart organic materials
AnnotationThe aim of the project is synthesis of spiropyrans with additional elements of chirality to reach an optically pure bentchtop-stable photoswitch. The prepared compounds will be incorporated into the scaffold of designed liquid crystalline matrices. The yielded materials will be further studied in terms of their dynamic physico-chemical properties with emphasis on light-controlled on/off switching of the liquid crstalline mesophase. Auxetic metamaterials with structurally programmable mechanical response
AnnotationThe fundamental challenge is physical realization of low-density 3D auxetic metamaterials with unique architecture and programmed deformation behavior. The research on hierarchical auxetics is in its infancy, it predominantly consists in prediction of their performance using sophisticated modeling and preparation of some macroscopic model structures. In spite of their very limited occurrence in natural materials, the several known examples confirm their advantages. In the systems considered, local mechano-mutability by spatially arranging multi-material unit cells should lead to substantial affecting of spatial profile of Poisson’s ratio, moduli of elasticity, toughness, control of acoustic damping, etc. Important tool will be targeted synthesis of auxetic unit cells and related functional nanocomposites based on both natural and synthetic constituents also including 3D printing techniques. Silicon-Based Battery Materials and Their Composites – Synthesis, Stabilization, and Electrochemical Performance
AnnotationThe PhD project will focus on the development, synthesis, and comprehensive investigation of silicon-based anode materials and their composites for next-generation lithium-ion, sodium-ion, and potentially multivalent batteries. Silicon is one of the most promising anode materials due to its exceptionally high theoretical capacity; however, its practical application is hindered by large volume expansion during cycling and insufficient structural and mechanical stability. The research will involve the preparation of silicon nanostructures (nanoparticles, nanowires, 2D Si layers) and the design of composite systems incorporating carbon materials, conductive polymers, or inorganic matrices to mitigate electrode degradation, improve electrical conductivity, and enhance cycle life. This includes optimizing surface chemistry, passivation strategies (SEI engineering), thin protective coatings, and the interfacial interactions between Si components and polymer binders. Electrochemical characterization will include measurements of specific capacity, coulombic efficiency, rate capability, diffusion kinetics, and long-term cycling stability. Special emphasis will be placed on correlating the microstructure and mechanical integrity of the composites with their electrochemical behavior under realistic operating conditions. The ultimate goal is to design and optimize next-generation silicon-based anodes that combine high capacity, robustness, and long-term stability, enabling their implementation in advanced rechargeable battery technologies. Bioactive coatings based on polyelectrolyte multilayer films of “charge-shifting” synthetic polycations for tunable protein release.
AnnotationIn biomedical applications, the release of growth factors (proteins) promoting vascularization from biomaterial surfaces is a key factor that supports the integration of biomaterials with the recipient tissue. An effective technique for the preparation of ultrathin coatings is the layer-by-layer technique ("LbL"), which is mainly used in engineering applications. The project aims to develop bioactive LbL films consisting of “charge-shifting” polycations based on poly(dimethylaminoethyl acrylate) (PDMAEA) and the polyanion heparin, which will release the growth factors VEGF and FGF-2 that stimulate vascular cell growth. The gradual change in charge on the PDMAEA polymer will allow tuned decomposition of LbL films and thus controlled release of immobilized growth factors. Doctoral studies will include: 1. Study of the synthesis of PDMAEA and its statistic copolymers by RAFT polymerization, with the aim to obtain polycations with different charge content and hydrolytic stability. 2. Study of the dynamics of film formation and characterization of physicochemical and morphological film properties using advanced instrumental techniques such as surface plasmon resonance (SPR), quartz crystal microbalance (QCM-D), AFM, or CLSM. 3. Preparation of real LbL films using an automated coater for layer deposition and study of in vitro protein release as a function of composition and stability of LbL films. 4. Evaluation of the cytocompatibility of LbL films and the bioactivity of released proteins in collaboration with biologists. The interdisciplinary topic focuses on polymer chemistry and biomedical applications and is suitable for graduates of chemical disciplines, such as macromolecular chemistry, physical chemistry, biochemistry, etc. Biodegradable polymer systems based on thermoplasticized starch
AnnotationBiodegradable polymer systems show numerous technical and biomedical applications. Our team has long-term experience with a reproducible preparation of thermoplastic starch (TPS). TPS is cheap, biocompatible and completely biodegradable polymer. In this project, we aim at the development of TPS/PCL/MD/SiO2/Ag systems, where PCL = polycaprolactone (another biopolymer, added for better mechanical performance), MD = maltodextrin (bio-oligomer, acting as a lubricant that decreases processing temperature), SiO2 = silica nanoparticles (inorganic filler for higher stiffness and barrier properties), and Ag = silver nanoparticles (antibacterial properties). The multicomponent TPS/PCL/MD/SiO2/Ag systems could serve as a bio-material with tunable properties for numerous applications (such as antimicrobial packaging or mulching technology). The project comprises preparation of the above systems (by melt mixing), optimization of their composition and morphology (targeted modification of preparation protocols), characterization of their morphology (electron microscopy, vibrational spectroscopy, XRD), and properties (macro- and micromechanical properties), and participation in biodegradability testing (in collaboration with the University of Zagreb, Croatia). Biomimetic Fibrin-Based Coatings Enriched with Glycosaminoglycans and Peptides for Enhanced Endothelialization and Hemocompatibility of Vascular Implants
AnnotationThe long-term success of vascular implants, particularly coronary and neurovascular stents, critically depends on rapid restoration of a functional endothelial layer on their surface. Insufficient or delayed endothelialization substantially increases the risk of thrombosis, inflammation, and restenosis, representing one of the primary clinical challenges associated with current endovascular interventions. The aim of this PhD thesis is to develop a new generation of bioactive, hemocompatible coatings that mimic natural vascular healing processes and provide a unique combination of low thrombogenicity, anti-inflammatory properties, and active stimulation of endothelial growth. The research will focus on fibrin coatings produced through controlled polymerization directly on implant surfaces, which will be subsequently functionalized with sulfated glycosaminoglycans (e.g., heparin, fucoidan, hyaluronic acid) and synthetic peptides promoting wound healing. Fibrin serves as a biomimetic matrix capable of binding, stabilizing, and presenting bioactive molecules in a form similar to that found in the early phases of vascular wound healing. The PhD candidate will optimize fibrin polymerization parameters, tune coating morphology and thickness, and introduce bioactive motifs via specific covalent conjugation strategies, including modern bio-orthogonal click chemistries. The work will involve comprehensive structural and chemical characterization using AFM, SEM, confocal microscopy, FTIR-ATR, and SPR. Coatings will be evaluated using hemocompatibility assays (coagulation activation, platelet and complement activation), anti-inflammatory assessments (macrophage adhesion, M1/M2 polarization, cytokine release), and detailed endothelialization studies. These will include static and dynamic endothelial cell seeding, migration assays, proliferation analyses, and characterization of endothelial markers such as CD31, VE-cadherin, vWF, and eNOS. The expected outcome of the PhD thesis is a fully characterized multifunctional coating that accelerates endothelial regeneration while suppressing thrombosis and inflammation, thereby addressing key limitations of current vascular implant technologies. The candidate will obtain extensive expertise across macromolecular chemistry, surface biofunctionalization, materials characterization, cell–material interactions, hemocompatibility, and advanced microscopy, providing a strong foundation for future research or industrial careers in biomaterials and regenerative medicine. Calixarene derivatives containing pyridine or other heterocyclic units
AnnotationDesign and synthesis of new macrocyclic systems based on calixarene derivatives, containing pyridine or other heterocyclic nuclei within the skeleton. Their chemical behavior depending on the pH used, basic chemical transformations and conformational preferences will be studied. Use of the above-prepared macrocyclic systems for the design of new receptors capable of complexing selected charged or neutral species. Warped and Chiral Nanocarbons
AnnotationThe aim of the project is to develop the synthesis of new warped and chiral nanocarbons such as helical pi-conjugated macrocycles or cycloarenes. The chiral compounds will be prepared in optically pure form by resolution of racemates or by asymmetric synthesis. Their (chir)optical properties, self-assembly in 2D/3D space, aromatic character, and their conformational or redox behavior will be studied in order to identify their possible applications in chemistry or nanoscience. Design and synthesis of modified XNA as potential therapeutics
AnnotationThe topic of the dissertation will be the design and enzymatic synthesis of hypermodified xeno-nucleic acids with a combination of modifications at the base, sugar moiety and phosphate linkages. After optimization of the methodology, hypermodified XNA oligonucleotides will be prepared and tested as potential therapeutics. Electro- and Photoelectrocatalytic Water Splitting with MXenes – Development of Active and Stable Catalysts
AnnotationThe PhD project will focus on the development and investigation of MXenes and MXene-based hybrids as advanced electro- and photoelectrocatalysts for water splitting. The work will involve the synthesis of high-quality MXene layers and their functional modification (surface terminations, heteroatom doping, composite formation) to enhance catalytic activity toward the hydrogen evolution reaction (HER) and oxygen evolution reaction (OER). Additional emphasis will be placed on designing photoactive heterostructures that combine MXenes with semiconducting materials, enabling the study and optimization of photoelectrocatalytic mechanisms under various illumination conditions. The research will include comprehensive electrochemical characterization (Tafel analysis, EIS, stability studies, Faradaic efficiency), as well as in-situ and operando spectroscopic techniques to monitor surface transformations during catalysis. The project will also explore strategies for improving long-term stability, oxidation resistance, and interfacial charge transfer. The expected outcome is the development of highly active MXene-based catalytic systems with strong potential for hydrogen production and sustainable energy applications. Electrocatalytic Water Splitting Using Transition-Metal Dichalcogenides (TMDs) – Synthesis, Surface Engineering, and Mechanistic Studies
AnnotationThis PhD project will focus on the development, synthesis, and optimization of transition-metal dichalcogenides (TMDs; e.g., MoS₂, WS₂, MoSe₂, WSe₂) as electrocatalysts for water splitting, with emphasis on the hydrogen evolution reaction (HER) and oxygen evolution reaction (OER). Owing to their layered structure, tunable electronic properties, and abundant edge-active sites, TMDs represent a highly promising class of 2D catalytic materials. The work will involve preparing high-quality TMD layers via controlled synthesis methods (CVD, hydrothermal routes, sulfurization/selenization) followed by systematic surface engineering through defect creation, targeted intercalation, heteroatom doping (e.g., N, Co, Ni), and fabrication of hybrid composites with carbon materials or MXenes. These approaches aim to increase the density of active sites, improve conductivity, and enhance charge transfer kinetics. Comprehensive electrochemical characterization (LSV, Tafel analysis, EIS, stability testing) will be combined with product analysis. Operando techniques such as Raman spectroscopy, XPS, and XAS will be used to monitor surface transformations and identify reactive intermediates during catalysis. The overall goal is to establish clear structure–property–activity relationships in TMD-based electrocatalysts and to design efficient, stable, and cost-effective materials for sustainable hydrogen and oxygen production. Enantioselective transition metal catalysis using helically chiral ligands
AnnotationAs part of the doctoral project, a new class of helically chiral metal complexes for enantioselective catalysis will be developed. The main part of the work will focus on their design and synthesis. The catalytic potential of the prepared systems will then be verified on model enantioselective transformations catalyzed by transition metals, in particular on cycloisomerization of alkynes, (photo)redox, and activation processes. CO2-fixation reaction - a way towards sustainable polymers
AnnotationThe increasing production of greenhouse gas carbon dioxide (CO2) by human activities reached in 2021 more than 36 Gt and thus CO2 is generally considered as the biggest waste contributed to climate change. Current research is trying to address this challenge by capturing CO2 and using it as sustainable feedstock for polymer synthesis. The aim of this work is to investigate the possibilities of converting CO2 into polymer materials. The first route will be the CO2-oxirane (epoxy) coupling reaction, which leads to production of various cyclic carbonates, which are monomers for innovative polymer materials, e.g. non-isocyanate polyurethanes (NIPUs) and epoxides. The second approach will be the direct CO2 transformation into polycarbonates (PC). The third way will involve the ring-opening copolymerization of epoxide with CO2 leading to linear carbonate-ether copolymers. All the above-mentioned strategies will preferable utilize bio-based monomers to obtain fully renewable polymer materials. The important part of this PhD topic will be finding a suitable catalytic system for each synthetic path. Our preliminary experiments showed the successful CO2-epoxy cycloaddition in the presence imidazolium and metal-based ionic liquids (ILs). Due to ILs’ countless possible anion/cation combinations and their exceptional set of properties (low vapor pressure, negligible flammability, high thermal and chemical stability), they can seem to be suitable candidates to catalyze the cycloaddition reaction of epoxide and CO2 with tunable selectivity towards linear / cyclic carbonate and ether formation. As part of the doctoral project, a student's several-month internship at foreign collaborating workplace (INSA Lyon, France) is assumed. The candidates should have good communication skills in English (both in speaking and writing), should be able to work both in a team and independently. Active participation on foreign internships, trainings and scientific conferences is expected. Fluorides and rare earth oxides for optical applications
AnnotationFluorides and oxides of rare earths are interesting for their optical properties, especially in the field of nonlinear optical phenomena. Their preparation, research and characterization, primarily in terms of phase and elemental composition, will be the main focus of this work. Other monitored parameters will be the morphology of the prepared materials and their application potential. Photoelectrochemical conversion using hybrid 2D-based catalysts
AnnotationThe dissertation topic combines experimental and theoretical studies of catalytic hybrid nanomaterials for the photoelectrolytic synthesis of energy-rich compounds. Attention will be focused on the hydrogen evolution reaction (HER), the synthesis of hydrocarbons from CO2 (CRR) and possibly ammonia from nitrogen (NRR). Nanostructured layered compounds such as MXenes, C3N4 or chalcogenides functionalized with nanoparticles, polyoxometalates and/or transition metal complexes will be used as catalysts. Theoretical modeling of these systems will include DFT calculations of the electronic structure of layered nanomaterials with a focus on the band gap width, the position of the valence and conduction bands, the work function and the surface energy, depending on the number of layers. Furthermore, the binding energies of functional units to 2D surfaces will be calculated and the energetics of the reaction coordinates of the catalyzed reaction itself will be monitored. Photo-electrochemical reduction of CO2 by transition metal complexes
AnnotationThe aim will encompass the synthesis and characterization of ligand-metal complexes (group 6 metals and Re or Mn). These compounds will be studied by electrochemical and spectroelectrochemical (UV-Vis-NIR and IR regions). Multiplicity-Controlled Photochemical Processes
AnnotationExcited state multiplicity plays a critical role in governing photochemical reactivity. Most of the excited organic molecules can exist either in the singlet or triplet excited state. Singlets are typically short-lived (~ns) and exhibit zwitterionic character, whereas triplet excited states, with their diradical-like nature, are significantly longer-lived (~?s–ms), enabling diffusion-controlled intermolecular processes. The contrasting photochemical behaviour of singlets and triplets has been mostly understood phenomenologically, with their lifetimes and zwitterionic or diradical-like character often cited as key factors. However, the intrinsic reason for this behaviour difference, electronic spin, is often neglected in the rationalization of photochemical reactivity. The PhD candidate will address this gap by designing and studying multiplicity-controlled photoreactions based on fundamental principles, reflecting spin-spin interactions and spin-selection rules. Photooxidations and fotoreductions catalysed by redox inactive metals
AnnotationReplacement of iridium- and ruthenium-based catalysts with less expensive and more abundant alternatives represents a long-standing but still unresolved challenge in photoredox catalysis. An innovative solution could be the use of metal ions, such as Sc(III), Y(III), Zn(II) or Mg(II), which are considered redox- and photo-inactive species. Redox-inactive metal ions are presently used exclusively as Lewis acids and no one has yet considered using them as photoredox catalysts. Nevertheless, our preliminary experiments revealed a surprising photocatalytic activity of Sc(III) ions. This project aim is to introduce redox-inactive metal ions as simple photoredox catalysts and use them to develop novel methodologies for oxidative functionalisation of various types of C–H bonds, allowing C–O, C–S, C–N and C–C bond formation. The new photocatalytic systems will work under aerobic conditions with visible light and will be based on the oxophilicity of a redox-inactive metal ion and the metal ion-coupled electron transfer. Photoreductions will also be studied under inert conditions. Photogearing at the Molecular Scale: Mechanistic Principles for Converting Brownian Motion into Directed Rotation
AnnotationThe dissertation will focus on the mechanistic principles underlying photogearing at the molecular scale, i.e. the conversion of a light-driven primary motion into a mechanically coupled secondary rotation. While many molecular systems undergo photoinduced conformational changes, only a limited number enable controlled transmission of motion analogous to macroscopic gears. This work aims to elucidate how unidirectional molecular motors can be combined with originally Brownian rotors to enforce correlated, directional motion through steric, conformational, or supramolecular constraints. The project will integrate molecular design, synthesis, photochemical and kinetic studies, and mechanistic analysis to distinguish genuine mechanical coupling from mere energetic or allosteric effects. Particular attention will be paid to identifying structural features that govern efficiency, directionality, and robustness of motion transfer. The results are expected to provide general design rules for photogearing systems and contribute to the fundamental understanding of motion control in artificial molecular machinery. Glycine alkoxyamines for New Bioconjugation Methodologies
AnnotationWe just accomplished approaches to glycine alkoxyamines, which hold large promise in bioconjugation. With this project the potential of these non-natural amino acid derivatives for approaching new peptide architectures will be explored. Hybrid salts of 3d metals: synthesis, structure, and magnetic studies
AnnotationThis PhD project combines the synthesis of new compounds, their fundamental characterizations, and magnetic studies. The target compounds are hybrid organic-inorganic systems composed of an organic cation, a 3d metal cation, and an anion of oxoacid, which will be specifically selected to achieve magnetically interesting scenarios, inspired by purely inorganic systems. This project will be predominantly experimental, and the specific direction will be adjusted according to the candidate's preferences. It will involve, besides the synthesis, structural studies (XRD, potentially 57Fe Mössbauer spectroscopy), magnetic characterizations (SQUID magnetometry), including high-pressure experiments (up to tens of GPa), and potentially experiments on large infrastructures (neutron diffraction). The candidate may also participate in computational studies to guide the synthesis and analyze the experimental data. Magnesium silicate hydrates with alternative silicon dioxide sources: innovative, eco-friendly and 3D printable construction materials
AnnotationThe PhD thesis aims to a sustainable MgO-SiO2 binder using alternative SiO sources, minimizing the carbon footprint and environmental impact. The focus will be on 3D-printable composites, rheology optimization, hydration kinetics, and durability, offering eco-friendly alternatives to Portland cement. Chemical Functionalization of Two-Dimensional Silicon and Germanium – Synthesis, Stabilization, and Tailoring of Their Physicochemical Properties
AnnotationThis PhD project will focus on the synthesis, chemical modification, and comprehensive investigation of two-dimensional forms of silicon and germanium, including silicene, germanene, and related 2D derivatives. These materials constitute a unique class of tunable 2D semiconductors whose electronic and optical properties can be strongly influenced through controlled chemical functionalization. The work will involve preparing stable 2D Si/Ge layers via exfoliation, epitaxial growth, or chemical conversion methods, followed by systematic functionalization through halogenation, hydrogenation, oxidation, organic surface grafting, or intercalation. The candidate will examine how these functional groups and reactions modify the structural ordering, electronic band structure, carrier mobility, optical transitions, and chemical reactivity. The project will also include studies of environmental stability, interactions with other 2D materials (e.g., TMDs, graphene, MXenes), and the fabrication of simple electronic and optoelectronic devices to evaluate the application potential of functionalized silicene and germanene. The expected outcome is a detailed understanding of functionalization mechanisms in 2D silicon and germanium, along with the development of strategies to tailor their properties for nanoelectronics, sensing, photonics, and other advanced technologies. Chemistry of inorganic analogues of graphene - nanostructures based on pnictogens
AnnotationThe dissertation project focuses on investigating covalent and non-covalent interactions in layered pnictogen materials (such as phosphorene, arsenene, and antimonene) and on developing strategies to enhance their long-term chemical and structural stability. Mono- and few-layer 2D pnictogen structures will be obtained through optimized mechanical exfoliation processes and thoroughly characterized using advanced analytical techniques. The influence of specific non-covalent interactions with substituted, delocalized organic systems will be examined to assess their effect on electronic transport and surface stability. In parallel, radical-based reactions will be employed to explore possibilities for targeted covalent functionalization, aimed at improving chemical robustness, tuning electronic properties, and enhancing compatibility with other 2D materials. Finally, methods for fabricating functional microelectronic components—such as FET transistors, sensors, and photodetectors—based on functionalized pnictogen nanostructures will be developed and optimized. The overall objective is to evaluate the application potential of chemically modified inorganic graphene analogues and to propose pathways for their integration into next-generation electronic and optoelectronic devices. PRMT5/MAT2 inhibitors with potential anticancer properties
AnnotationThe aim of the project is to design, synthesize, and structurally optimize (SAR studies) potential inhibitors of the PRMT5/MAT2 enzymes. Such inhibitors exhibit antitumor activity in cancers with MTAP deletion or inhibition. The biological properties of the prepared compounds will be evaluated in collaboration with other research groups. Aerosol interaction with air humidity
AnnotationThe hygroscopicity of aerosol particles is their ability to bind water vapor. This changes their shape, size, and phase behavior. This property affects the ability of particles to become cloud condensation nuclei, their optical properties, global climate change, and human health. The project aims to study the interaction of aerosol particles with air humidity in the laboratory. Aerosol particles composed of substances commonly found in atmospheric aerosol will be generated and their hygroscopicity will be studied using a newly constructed humidification chamber. The size of the prepared dry particles will be measured using an APS aerodynamic particle spectrometer, and these particles will then be fed into a humidification chamber that simulates conditions in the human respiratory tract. The size of the humidified particles under conditions corresponding to the first branchings of the bronchi will again be measured by the APS spectrometer. The experimental results will be compared with model predictions. Required education and skills • Master's degree in chemical engineering, physical chemistry, organic technology, chemical physics, meteorology, environmental sciences, • willingness to do experimental work, learn new things, and work in a team. Electrocatalytic CO₂ Reduction on MXene-Based Catalysts – Synthesis, Functional Engineering, and Mechanistic Studies
AnnotationThis PhD project will focus on developing MXene-based materials as advanced electrocatalysts for the electrochemical reduction of carbon dioxide (CO₂RR). The work will involve the synthesis of high-quality MXenes (such as Ti₃C₂Tₓ, Mo₂CTₓ, V₂CTₓ and related systems), followed by surface functional engineering and controlled modification of surface terminations (–O, –OH, –F, –Cl, –S) that critically influence catalytic activity, selectivity, and long-term stability. The research will investigate fundamental reaction pathways leading to valuable reduction products including CO, formate, methane, and other C1/C2 hydrocarbons. Particular emphasis will be placed on understanding how defects, heteroatom doping (e.g., N, S, Se), MXene–metal hybrids, and MXene–carbon composites modulate CO₂ adsorption, activation, and intermediate binding energetics. The candidate will perform comprehensive electrochemical characterization (LSV, CV, Tafel analysis, EIS), Faradaic efficiency assessment, and product identification using gas and liquid chromatography. Advanced in-situ and operando spectroscopic techniques (Raman, FTIR, XAS) will be employed to correlate structural evolution and surface chemistry with catalytic performance. The expected outcome is a detailed understanding of structure–function relationships in MXene-based catalysts and the development of high-performance catalytic systems for sustainable CO₂ electroreduction. Catalytic Synthesis of Bioactive Atropisomers by Aromatic Substitution
AnnotationOur group recently developed nucleophilic aromatic substitutions for synthesis of drug-like atropisomers, chiral conformational isomers originating from restricted single bond rotation. In this context, we discovered a fluoride-catalyzed strategy that is remarkably efficient. In this PhD thesis, we will explore this reactivity for synthesis of atropisomers and other bioactive compounds. The primary goal is to advance the field of catalytic organic synthesis. In collaboration, we will evaluate biological activity of the unique molecules synthesized during the project. Combined Thermodynamic and Structural Study of Polymer Systems Utilizing In-Situ VT-XRD.
AnnotationCombined Thermodynamic and Structural Study of Polymer Systems Utilizing In-Situ VT-XRD. Transition metal complexes for DNA photooxidation
AnnotationThe aim of this work is to synthesize polypyridyl ligands and their metal complexes (Ru, Cr, Cu etc.), which are well-known DNA intercalators. The influence of polypyridyl ligand substituents on DNA oxidation will be investigated using electrochemical and spectroelectrochemical methods. Luminescent molybdenum clusters for radiodynamic therapy under hypoxic conditions
AnnotationOur work involves the synthesis of Mo6 clusters along with studies of their stability, luminescence, and biological activity. While these clusters traditionally generate singlet oxygen upon activation by visible light,we have recently demonstrated that they can also be efficiently excited by X-rays. Our most recent results in radiodynamic therapy (RDT) show that Mo6 clusters can act as effective radiosensitizing agents capable of producing cytotoxic species in deep tumor tissues with reduced oxygen levels. Consequently, these clusters represent a valuable platform for the development of next-generation therapeutics aimed at enhancing cancer radiotherapy. Magneto-electric nanoparticles: from preparation to inkjet printing
AnnotationThis PhD project focuses on the development of well-defined magneto-electric nanoparticles (MENPs), with a high magneto-electric coefficient and tunable magnetic behaviour, for inkjet printing of proof-of-concept electronic components. The project primarily targets core-shell heterostructures that combine magnetostrictive ferrite cores and ferroelectric titanate shells. The candidate will aim to develop a novel synthetic route for these specific particles. Experimental work will involve analysis of the magnetic behaviour of the nanoparticle cores (SQUID magnetometry) and the magnetoelectric effect of the complete particles (a custom-built setup for PPMS). The project will involve structural studies (XRD and TEM) and complex physicochemical characterizations of these nanomaterials. Moreover, colloidally stable suspensions MENPs will be prepared, and preliminary studies on the properties and performance of inkjet-printed electronic components will be performed. The candidate may also participate in computational studies to support the analysis of experimental data. Microwave plasma chemical conversion of biomethane to hydrogen and carbon nanoparticles
AnnotationThis thesis will investigate the chemical conversion of biomethane into hydrogen and carbon nanoparticles using microwave plasma pyrolysis. Plasma behavior and reaction mechanisms will be examined through diagnostic techniques such as optical emission spectroscopy, while the produced gases will be monitored online using mass spectrometry to evaluate process conditions and identify optimal operating parameters. The resulting carbon nanomaterials will be characterized using advanced analysis techniques (e.g., transmission electron microscopy, particle size analysis, Raman spectroscopy, scanning transmission electron microscopy with elemental mapping, and X-ray diffraction). Modular synthesis of helical aromatic compounds for applications in materiál chemistry
AnnotationThe main aim of the work is to develop a universal procedure for the synthesis of polyaromatic compounds, valued in materials chemistry especially for their optical properties. A modular approach will enable a preparation of such substances of arbitrary dimensions and will further open up a space for further modification of physico-chemical properties of these compunds. Cerium nanooxides for environmental and bio-applications
AnnotationThe work focuses on the preparation of nanostructured cerium oxides by various "wet chemical" methods and their use in environmental and bio-applications. The exceptional surface redox properties of CeO2 nanostructures enable the reactive adsorption/catalytic decomposition of dangerous pollutants (such as pesticides or pharmaceuticals in water), but also, chemical warfare agents. In addition, CeO2 nanoparticles show unusual pseudo-enzymatic properties and can thus mimic enzymes in living organisms, which could lead to the development of artificial enzymes, so-called nanozymes. Design and synthesis of MTAN inhibitors
Annotation5?-Methylthioadenosine nucleosidase (MTAN) is a recognized target for potential antibacterial agents. Thus, MTAN inhibitors may have potential in the treatment of bacterial infections. The aim of the project is to design, synthesize, and structurally optimize (SAR studies) MTAN inhibitors. The biological properties of the prepared compounds will be evaluated in collaboration with other research groups. Design and Synthesis of Novel Non-Hallucinogenic Psychoplastogens
AnnotationPsychoplastogens are small molecules that can induce changes in neural tissue such as neurogenesis and spinogenesis. These compounds are valuable therapeutics for many psychiatric disorders, including depression, addiction, post-traumatic stress disorder (PTSD), and neurodegenerative diseases (Alzheimer's disease, Parkinson's disease). Classical psychedelics like LSD, psilocybin, and dimethyltryptamine possess psychoplastogenic effects, but their strong hallucinogenic properties complicate their use in psychiatry. This dissertation focuses on the design and synthesis of psychoplastogens that are agonists of serotonin 2A receptors and lack hallucinogenic effects. In silico methods will be used for the design of the final structures. Synthesised compounds will be used in further neuropharmacological research and the development of new psychoplastogenic therapeutics. Designing new MXene architectures: carbon-source engineering for tunable structure and performance
AnnotationThis PhD project, fully funded by the GACR Junior Star grant, focuses on the controlled synthesis and optimisation of MAX phases and their transformation into MXenes, with an emphasis on tailoring morphology using diverse carbon sources. The research will investigate how different carbon allotropes influence MAX phase formation, structural evolution, and the resulting MXene architecture. By systematically tuning the carbon environment during synthesis, the project aims to synthesise MXenes with engineered morphologies, including tubular, porous, and other emerging structures, and to understand how these structural variations affect surface chemistry, defect distribution, and overall functional properties. This project offers an exciting opportunity to expand both the structural and functional diversity of the MXene family through carbon-guided design. Key benefits: - Hands-on training in material synthesis (solid-state reactions, molten salts, etching). - Experience in structural, morphological, and surface characterisation (SEM, TEM, EDS, XRD, Raman spectroscopy, AFM, XPS). - Understanding of structure–property–performance relationships in MXenes and their impact on functional performance in energy applications - Work within an international and interdisciplinary environment. - Participation in international conferences, workshops, and training schools. - Collaboration abroad with research partners. Novel types of substitutions at boron and carbon atoms in carboranes and metallacarboranes directed to non-taditional drugs
AnnotationAim of this topic is design and synthesis of novel structural blocks that can be incorporated to design of non-traditional drugs. Attention will be given to stereochemistry of substitution on cluster molecules. New ways to influence the conformational mobility of higher calixarenes and their analogues
AnnotationThe work is focused on studying the possibilities of immobilizing or influencing the conformational behavior of larger calixarenes with five or more phenolic subunits, or their analogues. While common methods of fixing conformers in calix[4]arene chemistry consist in alkylation of the lower rim, these methods do not work for higher calixarenes. The aim of the work is to achieve influencing the conformational behavior by rigidifying the upper rim, through bridging neighboring aromatic groups. The prepared derivatives will be further studied as potential receptors for complexation of selected species. P-Chiral Phosphines as Asymmetric Organocatalysts
AnnotationRecently we discovered new P-chiral ligand architectures, which were successfully applied as ligands in asymmetric gold catalysis. In general, phosphines are at the same time useful organocatalysts in a number of reactions. With this project the potential of our P-chiral phosphines in asymmetric organocatalysis will be explored such as cycloadditions, Michael additions, allylic substitution or umpolung reactions. Advanced Functional Polyelectrolyte Films for Antibacterial Applications
AnnotationAntibacterial surfaces are increasingly important for reducing microbial contamination and infection risks in healthcare, food processing, and related industries. With the growing challenge of antimicrobial resistance and persistent surface contamination, there is a strong demand for durable, biocompatible, and environmentally safe antibacterial coatings. Current technologies include passive surfaces that prevent adhesion and active surfaces that kill microbes on contact, though achieving long-lasting, biocompatible, and environmentally safe performance remains a challenge. This PhD project focuses on the development of advanced polycation-based polyelectrolyte antibacterial surfaces using the layer-by-layer (LbL) assembly technique, which enables precise control over film thickness, composition, and functionality. The project will investigate various types of positive charges in polycation layers and their influence on film structure, stability, and antibacterial performance. In addition, the integration of biologically active agents such as enzymes and antimicrobial peptides into LbL films will be explore to create the coatings with long-term, synergistic anti-adhesive and active antibacterial functionality. Polyelectrolyte polymer particles for delivery of pro-angiogenic growth factors to support vascularization of polymer scaffolds in bioapplications.
AnnotationIn tissue engineering, vascularization of polymer scaffolds developed for tissue replacement is crucial for their functionality in the recipient body. Direct administration of free pro-angiogenic proteins (e.g., VEGF or FGF-2) often fails to produce effective results. Polymer-based delivery systems, such as nano- and microparticles, enabling controlled and localized release of growth factors, are therefore intensively studied. The PhD project aims to develop polyelectrolyte nano- and microparticles based on charge-shifting poly(dimethylaminoethyl acrylate) (PDMAEA) polycations for the controlled growth factor delivery. The gradual loss of charge on PDMAEA enables controlled particle degradation, sustained release of growth factors, and reduced toxicity, making these systems attractive for biomedical applications. The doctoral research will focus on i) the synthesis of PDMAEA-based block copolymers via RAFT polymerization to tune the particle charge density and corona composition, ii) the preparation of polyelectrolyte particles and characterization of their physicochemical properties (DLS, zeta potential measurements, IR spectroscopy, ITC, TEM), iii) investigation of protein loading and release behavior using ELISA, and iv) the evaluation of particle biocompatibility and protein bioactivity in collaboration with biologists. The interdisciplinary topic focuses on polymer chemistry and biomedical applications and is suitable for graduates of chemical disciplines such as macromolecular chemistry, physical chemistry, biochemistry, etc. Proton conductive phopshonate metal-organic frameworks
AnnotationThe constantly increasing world consumption of energy and the connected environmental problems require the development of new ecological energy sources, which includes a wider utilization of fuel cells and batteries. Proton-exchange membranes are an important part of the devices that separates the space of electrode half-cell reactions. Up to now, proton-exchange membranes are made of mainly conductive polymers which have several drawbacks; high manufacturing price, permeability for some fuels or amorphous character, which does not allow deeper understanding of the transport mechanism. Metal-organic frameworks (MOFs) are crystalline porous coordination polymers composed of metallic nodes interconnected by two- or multidentate organic ligands. The crystalline character of MOFs, the presence of pores, the possibility of rational design of the structures and tuning psysicochemical properties of the pores make MOFs suitable candidates for proton conductive materials. The aim of the work is preparation of new MOFs based on N-heterocyclic phosphonate building blocks trying to maximize their proton conductivity. By introducing phosphonate or phosphinate functional groups onto various N-heterocyclic molecules (bipyridine, pyrazine, imidazole), new ligands will be synthetized, from which new coordination polymers will be prepared and the proton conductivity of the resulting materials will be studied. Synthesis and investigation of azadienes for use in bioorthogonal reactions
AnnotationCílem projektu je navrhnout a syntetizovat různé heterodieny, jako jsou tetraziny a triaziové soli, a studovat jejich reaktivitu s neaktivovanými a napjetými dienofily. Bude zkoumán vliv různých substituentů na reakční kinetiku a potenciál sloučenin pro fluorogenní značení. Nejslibnější sloučeniny budou testováni na modelových biologických systémech, včetně proteinů (nebo jiných biomolekul) a buněčných kultur. Synthesis of compounds modulating the dynamics of the actin cytoskeleton
AnnotationThe dynamics of the actin cytoskeleton play a key role in cell motility, and influencing this process is crucial for the development of compounds with migrastatic activity. The aim of this work is to design and prepare compounds that will affect actin polymerization based on direct interaction with actin and/or regulatory proteins involved in actin polymerization. Rational design of compounds will be used, as well as a classical approach to studying the SAR. Recycling of polyisocyanurate foams
AnnotationThe plastic waste treatment and a sustainable use of synthetic polymers is one of the major environmental challenges of the 21st century. Polyisocyanurate (PIR) foams are highly rigid foams primarily used for thermal insulation in construction, refrigeration, and other industries. They are produced by reacting polyols (which are typically derived from petroleum-based products) with isocyanates, resulting in a foam that has excellent insulating properties and resistance to fire and heat. PIR foams are chemically similar to polyurethane foams, but they have higher degree of isocyanurate content, which enhances their thermal stability and fire resistance. Recycling PIR foams is therefore challenging because their covalent structure is highly crosslinked and contains hydrolytically highly resistant structures that do not easily undergo chemical depolymerization. The aim of the PhD topic is to study the degradation behavior of PIR foams with the aim of finding a suitable method for their chemical recycling (solvolysis). The PhD candidates should have good communication skills in English (both in speaking and writing), should be able to work both in a team and independently. Active participation on foreign internships, trainings and scientific conferences is expected. Rheology and processing of particle filled polymer melts
AnnotationPolymerní kompozity jsou materiály s vysokým aplikačním potenciálem pro použití v pokročilých technologiích. Téma se zabývá řízením vlastností mezifází polymer-plnivo pomocí povrchové modifikace částic plniva a jeho vlivem na reologické vlastnosti kompozitů se zvláštním důrazem na výskyt tokových nestabilit (žraločí kůže, lom taveniny atd.), které omezují zpracovatelské okno polymerních materiálů. Přestože reologické jevy vyvolané přítomností plniva jsou v literatuře popsány, jejich podstata a vysvětlení je často stále nejasná. Systematická studie vlivu velikosti částic, jejich koncentrace a povrchové modifikace na elastické vlastnosti polymerních tavenin a vznik tokových nestabilit bude základem této doktorské práce. Práce je převážně experimentální s použitím technik oscilační a kapilární reologie. Struktura kompozitů bude zkoumána zejména metodami elektronové mikroskopie a termické analýzy. Biodegradable polymers for advanced applications
AnnotationThe aim of the work is to prepare, characterize, and study the degradation of polymer materials derived from natural raw materials, e.g., cellulose produced by an environmentally friendly process, or derived from ε-caprolactone monomer produced from natural raw materials. The materials will be studied in the form of fabrics, membranes, nanofibers, or microspheres. Degradation will be studied in model environments (e.g., buffers of various pH values) or in environments simulating real-world use (washing cycles, composting tests). The extent of degradation will be described using modern analytical methods. Growth and Investigation of 2D Magnetic Halides – New Materials for Spintronics and Quantum Technologies
AnnotationThe PhD project will focus on the synthesis, growth, and characterization of two-dimensional magnetic halides (e.g., CrI₃, CrCl₃, FeCl₂, NiBr₂ and related layered systems), which provide a unique platform for studying magnetism in the atomically thin limit. The work will involve optimizing growth methods (CVT, PVT, and potentially CVD), producing high-quality bulk crystals, and exfoliating them into monolayers and few-layer flakes with controlled thickness. The research will include comprehensive characterization of magnetic properties (such as magnetic hysteresis, temperature-dependent magnetism, and magneto-optical effects including MOKE) and their variation with thickness, chemical composition, surface termination, and possible doping. The candidate will also fabricate and study van der Waals heterostructures combining magnetic halides with other 2D materials to investigate spin ordering, magnetic phases, interlayer coupling, and the tunability of magnetism through electric fields, pressure, light, or molecular intercalation. Self-healing and recyclable polymer networks prepared from renewable resources
AnnotationThe aim of this PhD topic is to prepare and characterize polymer materials based on renewable raw materials (carboxylic acids, vanillin derivatives, furan compounds, etc.). The prepared materials will be dynamically crosslinked through reversible covalent bonds and non-covalent interactions (hydrogen bonding, metal-ligand coordination bonds, complex formation or electrostatic/ionic interactions), which will give the material self-healing and recyclable properties. As part of the doctoral project, a student internship of several months at a foreign collaborating institution (Cracow University of Technology, Poland) is planned. Applicants should have good communication skills in English (spoken and written), and should be able to work in a team and independently. Active participation in foreign internships, trainings and scientific conferences is expected. Self-assembled films of 2D materials
Annotation2D materials, such as graphene, exhibit planar crystalline nanostructures with remarkable transport and mechanical properties. However, these properties are highly dependent on the molecular structure of the crystals and are often limited by the resistivity at their edge junctions. High-quality edge contacts are typically achieved through chemical vapor deposition (CVD), which restricts the scalability of these materials in large films and bulk 3D structures. This thesis aims to address this limitation by utilizing novel methods to hydrolyze the edges of 2D materials and enable the self-assembly of 3D structures. The edge junctions of the self-assembled 2D sheets are rich in defects, radicals, and oxygen under confinement, creating intrinsic nanoreactors. These nanoreactors will be employed to in-situ synthesize metal nanoparticles, which are expected to modulate the edge-junction resistance, enhancing the material's overall performance. Selection and optimization of modified XNA aptamers
AnnotationThe topic of the dissertation will be the enzymatic synthesis of hypermodified xeno-nucleic acids and their use in aptamer selection. It will be necessary to develop enzymatic synthesis of modified XNA libraries, selection of binding sequences, reverse transcription into DNA and sequencing. The goal will be the development of stable aptamers binding target molecules (biomarkers, proteins, etc.). Low-valent carbon compounds as triplet luminophores for OLED applications and photocatalysis
AnnotationThe recent discovery of unique photophysical properties of low?valent carbon compounds?[https://doi.org/10.26434/chemrxiv-2025-4vvdm-v2] opens the way to modern luminophores based exclusively on light elements, which have the potential to replace—or at least supplement—established heavy?metal luminescent compounds. The proposed PhD project combines synthetic work with advanced spectroscopic measurements. The primary goal is to establish structure-luminescent relationships, including the structural control over the population of triplet states and their lifetimes, the wavelength of emitted radiation, and the energy gap between relevant excited states. Target luminophores with optimized properties will subsequently be tested as photocatalysts (especially in processes that rely on triplet-triplet energy transfer) and as emitters for electroluminescent OLED devices. Stable Nitrogen-Heterocyclic Radicals for the Synthesis of Calcium Ion Channel Inhibitors
AnnotationThe efficient and versatile synthesis of nitrogen-rich scaffolds requires continuous development, given their relevance to medicinal chemistry and chemical biology. In this project, we explore the synthetic utility of stable N-heterocyclic radicals to uncover a novel chemical space. The pharmacological profile of the synthesized molecules will be assessed using patch-clamp electrophysiology of calcium ion channels to develop new molecules with analgesic properties. Nanoparticles for photoacoustic imagining studied by the photoacoustic and SERS effect
AnnotationThis PhD project focuses on studying one-pot–modified gold nanoparticles designed for advanced biomedical imaging. The goal is to characterize their plasmonic and surface properties and evaluate their suitability for near-infrared photoacoustic imaging and complementary SERS imaging that provides molecularly specific information. The project involves multimodal analysis of the prepared Au nanoparticles (photoacoustics, IR, Raman, SERS, UV–Vis, TEM, DLS) and investigation of the relationships between surface modification, optical response, and their potential applicability in biomedical diagnostics. Synthesis and Chiroptical Properties of Helicene-Derived Luminophores
AnnotationThe aim of the project is to prepare new helical TADF and excimer luminophores derived from helicenes and to study their chiroptical properties in solution and thin films (in particular circularly polarized luminescence) in order to identify suitable materials for future CP-OLED design. Synthesis of targeted kinase degraders as experimental therapeutics
AnnotationThe aim of the thesis will be to synthesize PROTACs for several kinases, which are validated targets in oncology and in CNS disorders. It will be focused on linker optimization, selection of ligase ligands and specificity for target kinase. Our recently developed highly selective small molecule heterocyclic kinase inhibitors will serve as a starting point. Synthesis of functionalized polymers and polymer membranes for electrochemical devices
AnnotationIon-exchange polymer membranes are widely used in laboratory and industrial applications. Major applications include electrochemical desalination of seawater and brackish water, wastewater treatment, separation of mixtures in the production of industrial chemicals and pharmaceuticals, separation of electrolytes from non-electrolytes in electrochemical devices such as electrolyzers, fuel cells and batteries. Recently, their use in hydrogen management and storage of excess electricity from renewable sources has become increasingly important. The use of so-called green hydrogen produced in electrolyzers is one of the ways in the transition to carbon-free energy. The topic includes the synthesis of polymers and polymer membranes bearing functional groups for a specific purpose. For example, sulfo and phosphono groups for cation-exchange or quaternary ammonium groups for anione-exchange materials. In addition, these polymers are useful for electrode design, as catalyst supports and for other applications. Preparative organic chemistry and polymerization reaction methods are commonly applied. Our department is flexible enough to give the potential candidate enough room to apply his or her ingenuity. Synthesis of Glycomimetic Organometallic Inhibitors of Galectins
AnnotationGalectins are proteins characterized by affinity to some galactosides and sequence homology. Their interactions with oligosaccharides are involved in many fundamental biological events. Inhibition of these interactions by synthetic analogs of endogenous saccharide agonists (glycomimetics) is of principal significance for their study and for drug development. The main goal of this PhD project is the synthesis and evaluation of hybrid glycomimetic galectin inhibitors based on the combination of carbohydrate and organometallic structural motifs. The incorporation of an organometallic moiety into the structure of a glycomimetic inhibitor can not only result in higher affinity or selectivity of inhibition, but also allow the study of interactions with galectins by electrochemical methods. The presence of the transition metal in the inhibitor molecule also expands the possibilities of its detection in cells and tissues. Required education and skills •Master degree in chemistry. •The willingness to acquire and apply advanced methods of organic synthesis. Synthesis of chiral carboranes and metallacarboranes, their separation and interactions with organic systms
AnnotationThis topics deals with synthesis of asymmetric boron clusters, separation of enantiomers, and study of their interactions with chiral organic platforms. Although the axial chirality resembles that of some chiral organic platforms like BONOL or ansa- substituted metallocenes, the chemistry remains grossly unerexpored and offers broad possibilities. Synthesis of Mono- and Multivalent Inhibitors of Tandem Galectins
AnnotationGalectins are a class of lectins (carbohydrate-binding proteins other than enzymes and antibodies) characterized by affinity to galactosides and sequence homology. So-called tandem galectins comprise two related but non-identical carbohydrate-binding domains (CRD) with partially different substrate specificities. Inhibition of tandem galectins by synthetic analogs of saccharides (glycomimetics) is of great importance in both fundamental research and drug development. The attachment of monovalent domain-specific inhibitors to suitable carriers will result in multivalent inhibitors that can inhibit both domains within the tandem galectin simultaneously and very effectively, if the right topology is achieved. The main goal of this PhD project is the synthesis and evaluation of glycomimetic inhibitors of individual domains and the verification of the hypothesis that an appropriate spatial arrangement of domain-specific inhibitors on a multivalent carrier can lead to high affinity inhibitors of tandem galectins due to a multivalent effect. Required education and skills •Master degree in chemistry. •The willingness to learn and apply advanced methods of organic synthesis. Syntéza nanokompozitů na bázi biopolymerů pro odstranění farmakologických kontaminantů: od syntézy polymerů k environmentálním aplikacím
AnnotationReleasing and accumulating contaminants, especially residues from pharmaceutical products, pose health risks to humans and have a negative and significant impact on the environment. This research focuses on the development of innovative nanocomposites derived from biomass-based monomers and biopolymers for the removal of environmental contaminants. The relationship between the structure and properties of materials for contaminant sorption is still not fully understood, which limits their effectiveness. The scope of this work will first involve the synthesis and comprehensive structural characterization of the prepared nanocomposites, including porosity, stability, mechanical and thermal properties, to explain their efficiency in terms of macromolecular structure and the presence of active sites. The second research objective will be the evaluation of nanocomposites in terms of their sorption efficiency. Sorption kinetics will be studied to identify the mechanism and rate of the sorption process. The third part of the research will focus on the biodegradation of the nanocomposites after sorption in bioreactors using effective microbial cultures (such as activated sludge). The efficiency of pollutant biodegradation within the nanocomposites will be monitored, followed by the biodegradation of the nanocomposite materials themselves. During the biodegradation process, the degradation mechanism and potential degradation products will be observed and analyzed using selected analytical techniques. This project offers an alternative to conventional methods, aiming to minimize environmental impacts and improve the efficiency of environmental technologies. Synthesis of polymer materials and polymer membranes for separation processes
AnnotationPolymer membranes are widely used in separation processes due to their versatility, efficiency, and cost-effectiveness. These membranes are designed to selectively allow certain molecules or ions to pass through while blocking others, making them ideal for applications like water filtration, gas separation, and dialysis. Polymer membranes can be tailored for specific separation tasks by adjusting factors such as pore size, chemical composition, and surface properties. Their applications range from purifying drinking water through reverse osmosis to separating gases in industrial processes. With ongoing advancements, polymer membranes continue to play a crucial role in improving the sustainability and performance of various separation technologies. The subject matter encompasses the synthesis of novel polymers and the functionalization of commercially available materials, with a particular focus on their use in the separation of chemical mixtures, including gases and enantiomeric mixtures. Methodologically, the work will encompass polymerization reactions, the introduction of functional groups into polymers, and the utilization of reactions employed in preparative organic synthesis. Our department is sufficiently flexible to allow the prospective candidate the opportunity to exercise their inventiveness. Thin films of multiferoic hexagonal ferrites with magnetoelectric properties
AnnotationThe scope of proposed PhD work involves study of thin films of multiferoic hexagonal ferrites with magnetoelectric properties synthetised by soft chemistry routes, and their complex chemical, microstructural, structural and physical characterization. The PhD study will be focused to the U, Y- and Z-type hexaferrites studied in the form of ceramics and thin films (https://www.annualreviews.org/doi/abs/10.1146/annurev-conmatphys-020911-125101). In particular, thin films will be prepared by means of chemical solution deposition methods using spin- or dip-coating deposition technique and their real (micro) structure (x-ray and neutron diffraction, electron microscopy) in relation to their functional properties will be studied. Physical investigations include measurements of electrical conductivity, dielectric properties complemented with the magnetic and magnetoelectric measurements (in cooperation with both domestic, and foreign physical laboratories). Shaping the morphology of MAX Phases and MXenes: the role of carbon allotropes to tailor their energy storage properties
AnnotationThis PhD project, fully funded by a GACR Junior Star grant, aims to explore the synthesis and optimisation of MAX phases and their transformation into MXenes with a focus on shaping their morphology to enhance their energy storage properties. The research will investigate how different carbon allotropes influence the formation of MAX phases and the structural characteristics of their MXene derivatives. By adjusting the carbon source during synthesis, the project will examine how variations in morphology, including tubular and other previously unexplored structures, affect the physical, chemical, and electrochemical behaviour of MXenes. This work will provide valuable insights into controlling surface chemistry and defects, key parameters governing MXene performance in energy storage systems. The project offers an exciting opportunity to contribute to the development and expansion of MXenes with improved properties for next-generation energy storage applications. Key benefits: - Hands-on training in material synthesis (solid-state reactions, molten salts, etching). - Experience in structural, morphological, and surface characterisation (SEM, TEM, EDS, XRD, Raman spectroscopy, AFM, XPS). - Understanding of structure–property–performance relationships in MXenes for electrochemical applications. - Work within an international and interdisciplinary environment. - Participation in international conferences, workshops, and training schools. - Collaboration abroad with research partners. Conformation and Hydrogen Bonding in Fluorinated Oligosaccharides
AnnotationImportant aspects in the design of carbohydrate-based therapeutics and materials are their conformational properties, which are partly determined by intramolecular hydrogen bonds (H-bonds). To achieve the desired properties of these compound classes, regio- and stereoselective introduction of fluorine is used. However, the influence of fluorine on the intramolecular H-bonds in oligosaccharides formed by functional groups vicinal to fluorine has not been investigated. The aim of this project is to investigate this influence and to elucidate the conformation of selected fluorinated oligosaccharides. Fluorinated disaccharides derived from N-acetyllactosamine and fluorinated trisaccharides derived from the Lewis X antigen (LewisX) will be synthesized and used to study inter-residue H-bonds including the non-conventional H-bond, which stabilizes LewisX. A combination of computational approaches and NMR experiments will be used to elucidate the conformational states and to detect and evaluate intramolecular H-bonds. Required education and skills •Master degree in chemistry. •The willingness to learn and apply advanced methods of organic synthesis and structure elucidation. The use of mechanical bond as a protecting group for the synthesis of porous materials
AnnotationPorous crystalline materials are used for the gas separation and storage, catalysis or chemical sensing. Their properties are strongly related to their porosity. However, one of the problems preventing the preparation of highly porous materials is the interpenetration – the interweaving of multiple crystal lattices. The aim of the project is to use the mechanical bond as a protecting group to prevent the interpenetration and, thus, the preparation of highly porous materials. Development and optimization of properties of REBCO superconductors prepared by the SDMG method
AnnotationREBCO (Rare Earth Barium Copper Oxide) belongs to a group of high-temperature superconducting materials that are often prepared by melt growth. The new SDMG (Single Direction Melt Growth) melt growth method exhibits higher robustness and better microstructure than the commercially used TSMG (Top Seeded Melt Growth) method. Despite these advantages, this method's limitations are the used seeds, which do not allow the growth of single-domain EuBCO/Ag crystals due to insufficiently high peritectic temperatures. This work will focus on increasing the peritectic temperature of SDMG seeds, optimizing their composition, and their corrosion resistance. The results of this work demonstrate and expand the potential of the SDMG method and its industrial application. Introduction of phosphorus and nitrogen atoms into aromatic structures
AnnotationMany synthetic strategies attempt to vary the shape and size of the π-conjugated system of aromatic compounds to obtain optimal properties. Recently, an alternative approach has come to the fore, which introduces a heteroatom (phosphorus, nitrogen) into the aromatic backbone, whose specific properties (chiral center on phosphorus, easy change of oxidation state, possibility of derivatization) significantly influence the behavior of the π-framework. This project deals with developing a simple and efficient preparation that introduces phosphorus and nitrogen into aromatic structures. The aim is to apply this approach to synthesizing polyaromatic compounds such as phenacenes, helicenes, or nanographenes containing phosphorus and nitrogen atoms. Required education and skills: •master's degree in organic chemistry, •experimental skill and practical knowledge of organic synthesis, •teamwork ability, •employment contract at ICPF. 3D printing of poly(glycerol sebacate) for tissue engineering applications
AnnotationPoly(glycerol sebacate) (PGS) is a biocompatible, biodegradable polyester with tunable mechanical properties, representing a promising alternative to non-degradable biomaterials—particularly for soft tissue regeneration and other applications requiring flexible elastomeric scaffolds. This PhD project aims to address current challenges in the 3D printing of PGS, which include optimizing the composition and viscosity of printable “inks,” developing efficient cross-linking methods, whether photo-induced or enzyme-mediated, and improving the biocompatibility of highly hydrophobic PGS through 3D printing of blended inks with biopolymers such as collagen. The student will gain experience in various synthesis techniques, 3D printing methods, and material characterization procedures using modern instrumentation (GPC, ¹H and ¹³C NMR, UV/VIS and fluorescence spectroscopy, Cellink BioX 3D printer, electron and optical microscopy, rheological measurements). A background in polymer chemistry, organic chemistry, or biomaterials is an advantage but not a requirement — what matters most is a willingness to learn and explore new areas in these fields. |
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Updated: 20.1.2022 16:26, Author: Jan Kříž