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Chemistry (FCT)
Doctoral Programme,
Faculty of Chemical Technology
The aim of the programme is to educate highly qualified creative workers and researchers with theoretical and practical knowledge in the field of strategy, design and practical implementation of synthesis of special inorganic and organic compounds, materials and polymers. Our aim is to deepen the chemical, physicochemical and chemical-engineering knowledge of the graduate who should be capable of independent creative activities and taking decisions in the field of research and development in chemistry as well as many related or interdisciplinary fields. CareersThe graduate will be able to design targeted syntheses of inorganic, organic and polymeric materials and coordination compounds with predefined physical, electrochemical, catalytic and biochemical properties to be applied in pharmacy, nanotechnology, electronics and catalysis, characterize them and theoretically interpret the obtained data. In the field of macromolecular chemistry, she/he will be prepared to solve problems related to the processing, recycling and use of polymers including the conservation and restoration of cultural heritage objects. Acquired knowledge may vary according to the nature of dissertation, ranging from purely experimental-interpretation character to knowledge based on quantum mechanics, thermodynamics or other theoretical models used to describe the structure and behavior of matter. The acquired skills also include knowledge of information technologies, ability to lead a scientific team, project preparation and management as well as publishing skills. Programme Details
Ph.D. topics for study year 2026/27Auxetic metamaterials with structurally programmable mechanical response
AnnotationThe fundamental challenge is physical realization of low-density 3D auxetic metamaterials with unique architecture and programmed deformation behavior. The research on hierarchical auxetics is in its infancy, it predominantly consists in prediction of their performance using sophisticated modeling and preparation of some macroscopic model structures. In spite of their very limited occurrence in natural materials, the several known examples confirm their advantages. In the systems considered, local mechano-mutability by spatially arranging multi-material unit cells should lead to substantial affecting of spatial profile of Poisson’s ratio, moduli of elasticity, toughness, control of acoustic damping, etc. Important tool will be targeted synthesis of auxetic unit cells and related functional nanocomposites based on both natural and synthetic constituents also including 3D printing techniques. Bioactive coatings based on polyelectrolyte multilayer films of “charge-shifting” synthetic polycations for tunable protein release.
AnnotationIn biomedical applications, the release of growth factors (proteins) promoting vascularization from biomaterial surfaces is a key factor that supports the integration of biomaterials with the recipient tissue. An effective technique for the preparation of ultrathin coatings is the layer-by-layer technique ("LbL"), which is mainly used in engineering applications. The project aims to develop bioactive LbL films consisting of “charge-shifting” polycations based on poly(dimethylaminoethyl acrylate) (PDMAEA) and the polyanion heparin, which will release the growth factors VEGF and FGF-2 that stimulate vascular cell growth. The gradual change in charge on the PDMAEA polymer will allow tuned decomposition of LbL films and thus controlled release of immobilized growth factors. Doctoral studies will include: 1. Study of the synthesis of PDMAEA and its statistic copolymers by RAFT polymerization, with the aim to obtain polycations with different charge content and hydrolytic stability. 2. Study of the dynamics of film formation and characterization of physicochemical and morphological film properties using advanced instrumental techniques such as surface plasmon resonance (SPR), quartz crystal microbalance (QCM-D), AFM, or CLSM. 3. Preparation of real LbL films using an automated coater for layer deposition and study of in vitro protein release as a function of composition and stability of LbL films. 4. Evaluation of the cytocompatibility of LbL films and the bioactivity of released proteins in collaboration with biologists. The interdisciplinary topic focuses on polymer chemistry and biomedical applications and is suitable for graduates of chemical disciplines, such as macromolecular chemistry, physical chemistry, biochemistry, etc. Biodegradable polymer systems based on thermoplasticized starch
AnnotationBiodegradable polymer systems show numerous technical and biomedical applications. Our team has long-term experience with a reproducible preparation of thermoplastic starch (TPS). TPS is cheap, biocompatible and completely biodegradable polymer. In this project, we aim at the development of TPS/PCL/MD/SiO2/Ag systems, where PCL = polycaprolactone (another biopolymer, added for better mechanical performance), MD = maltodextrin (bio-oligomer, acting as a lubricant that decreases processing temperature), SiO2 = silica nanoparticles (inorganic filler for higher stiffness and barrier properties), and Ag = silver nanoparticles (antibacterial properties). The multicomponent TPS/PCL/MD/SiO2/Ag systems could serve as a bio-material with tunable properties for numerous applications (such as antimicrobial packaging or mulching technology). The project comprises preparation of the above systems (by melt mixing), optimization of their composition and morphology (targeted modification of preparation protocols), characterization of their morphology (electron microscopy, vibrational spectroscopy, XRD), and properties (macro- and micromechanical properties), and participation in biodegradability testing (in collaboration with the University of Zagreb, Croatia). Biomimetic Fibrin-Based Coatings Enriched with Glycosaminoglycans and Peptides for Enhanced Endothelialization and Hemocompatibility of Vascular Implants
AnnotationThe long-term success of vascular implants, particularly coronary and neurovascular stents, critically depends on rapid restoration of a functional endothelial layer on their surface. Insufficient or delayed endothelialization substantially increases the risk of thrombosis, inflammation, and restenosis, representing one of the primary clinical challenges associated with current endovascular interventions. The aim of this PhD thesis is to develop a new generation of bioactive, hemocompatible coatings that mimic natural vascular healing processes and provide a unique combination of low thrombogenicity, anti-inflammatory properties, and active stimulation of endothelial growth. The research will focus on fibrin coatings produced through controlled polymerization directly on implant surfaces, which will be subsequently functionalized with sulfated glycosaminoglycans (e.g., heparin, fucoidan, hyaluronic acid) and synthetic peptides promoting wound healing. Fibrin serves as a biomimetic matrix capable of binding, stabilizing, and presenting bioactive molecules in a form similar to that found in the early phases of vascular wound healing. The PhD candidate will optimize fibrin polymerization parameters, tune coating morphology and thickness, and introduce bioactive motifs via specific covalent conjugation strategies, including modern bio-orthogonal click chemistries. The work will involve comprehensive structural and chemical characterization using AFM, SEM, confocal microscopy, FTIR-ATR, and SPR. Coatings will be evaluated using hemocompatibility assays (coagulation activation, platelet and complement activation), anti-inflammatory assessments (macrophage adhesion, M1/M2 polarization, cytokine release), and detailed endothelialization studies. These will include static and dynamic endothelial cell seeding, migration assays, proliferation analyses, and characterization of endothelial markers such as CD31, VE-cadherin, vWF, and eNOS. The expected outcome of the PhD thesis is a fully characterized multifunctional coating that accelerates endothelial regeneration while suppressing thrombosis and inflammation, thereby addressing key limitations of current vascular implant technologies. The candidate will obtain extensive expertise across macromolecular chemistry, surface biofunctionalization, materials characterization, cell–material interactions, hemocompatibility, and advanced microscopy, providing a strong foundation for future research or industrial careers in biomaterials and regenerative medicine. Calixarene derivatives containing pyridine or other heterocyclic units
AnnotationDesign and synthesis of new macrocyclic systems based on calixarene derivatives, containing pyridine or other heterocyclic nuclei within the skeleton. Their chemical behavior depending on the pH used, basic chemical transformations and conformational preferences will be studied. Use of the above-prepared macrocyclic systems for the design of new receptors capable of complexing selected charged or neutral species. Warped and Chiral Nanocarbons
AnnotationCílem projektu je vyvinout přípravu nových deformovaných a chirálních nanouhlíkových systémů, jakými jsou helikální pi-konjugované makrocykly nebo cykloareny. Chirální látky budou připraveny v opticky čisté formě skrze resoluci racemátů či pomocí asymetrické syntézy. Budou studovány jejich (chir)optické vlastnosti, samoskladba v 2D/3D prostoru, aromatický charakter a jejich konformační či redoxní chování s cílem identifikovat jejich možné aplikace v chemii či nanovědě. Design and synthesis of modified XNA as potential therapeutics
AnnotationTématem disertace bude design a enzymová syntéza hypermodifikovaných xeno-nukleových kyselin s kombinací modifikací na bázi, cukerné části a fosfátových spojkách. Po optimalizaci metodiky budou připravovány a testovány hypermodifikované XNA oligonukleotidy jako potenciální terapeutika. Enantioselective transition metal catalysis using helically chiral ligands
AnnotationV rámci doktorského projektu bude vyvíjena nová třída helikálně chirálních kovových komplexů určených pro enantioselektivní katalýzu. Hlavní část práce se bude věnovat návrhu jejich designu a syntéze. Katalytický potenciál připravených systémů bude následně ověřen na modelových enantioselektivních transformacích katalyzovaných tranzitními kovy, zejména na cykloisomerizaci alkynů, (foto)redoxních a aktivačních procesech. CO2-fixation reaction - a way towards sustainable polymers
AnnotationThe increasing production of greenhouse gas carbon dioxide (CO2) by human activities reached in 2021 more than 36 Gt and thus CO2 is generally considered as the biggest waste contributed to climate change. Current research is trying to address this challenge by capturing CO2 and using it as sustainable feedstock for polymer synthesis. The aim of this work is to investigate the possibilities of converting CO2 into polymer materials. The first route will be the CO2-oxirane (epoxy) coupling reaction, which leads to production of various cyclic carbonates, which are monomers for innovative polymer materials, e.g. non-isocyanate polyurethanes (NIPUs) and epoxides. The second approach will be the direct CO2 transformation into polycarbonates (PC). The third way will involve the ring-opening copolymerization of epoxide with CO2 leading to linear carbonate-ether copolymers. All the above-mentioned strategies will preferable utilize bio-based monomers to obtain fully renewable polymer materials. The important part of this PhD topic will be finding a suitable catalytic system for each synthetic path. Our preliminary experiments showed the successful CO2-epoxy cycloaddition in the presence imidazolium and metal-based ionic liquids (ILs). Due to ILs’ countless possible anion/cation combinations and their exceptional set of properties (low vapor pressure, negligible flammability, high thermal and chemical stability), they can seem to be suitable candidates to catalyze the cycloaddition reaction of epoxide and CO2 with tunable selectivity towards linear / cyclic carbonate and ether formation. As part of the doctoral project, a student's several-month internship at foreign collaborating workplace (INSA Lyon, France) is assumed. The candidates should have good communication skills in English (both in speaking and writing), should be able to work both in a team and independently. Active participation on foreign internships, trainings and scientific conferences is expected. Multiplicity-Controlled Photochemical Processes
AnnotationMultiplicita excitovaných stavů hraje klíčovou roli při řízení fotochemické reaktivity. Excitované organické molekuly se nejčastěji vyskytují v singletovém nebo tripletovém excitovaném stavu. Singletové stavy mívají typicky krátkou dobu života (řádově ns) a často vykazují výrazný zwitteriontový charakter. Naproti tomu tripletové excitované stavy mají díky své diradikálové povaze podstatně delší dobu života (řádově ?s až ms), což umožňuje i difuzně řízené intermolekulární procesy. Rozdílné fotochemické chování singletů a tripletů bylo dosud většinou interpretováno fenomenologicky, přičemž jako hlavní faktory se uvádějí právě jejich doby života a zwitteriontový či diradikálový charakter. Základní příčina tohoto rozdílu — elektronový spin — však při racionalizaci fotochemické reaktivity často zůstává opomíjena. Doktorand(ka) se proto zaměří na návrh a studium multiplicitně řízených fotoreakcí, vycházejících z prvních principů a zohledňujících spin–spinové interakce i spinová výběrová pravidla. Photooxidations and fotoreductions catalysed by redox inactive metals
AnnotationReplacement of iridium- and ruthenium-based catalysts with less expensive and more abundant alternatives represents a long-standing but still unresolved challenge in photoredox catalysis. An innovative solution could be the use of metal ions, such as Sc(III), Y(III), Zn(II) or Mg(II), which are considered redox- and photo-inactive species. Redox-inactive metal ions are presently used exclusively as Lewis acids and no one has yet considered using them as photoredox catalysts. Nevertheless, our preliminary experiments revealed a surprising photocatalytic activity of Sc(III) ions. This project aim is to introduce redox-inactive metal ions as simple photoredox catalysts and use them to develop novel methodologies for oxidative functionalisation of various types of C–H bonds, allowing C–O, C–S, C–N and C–C bond formation. The new photocatalytic systems will work under aerobic conditions with visible light and will be based on the oxophilicity of a redox-inactive metal ion and the metal ion-coupled electron transfer. Photoreductions will also be studied under inert conditions. Photogearing at the Molecular Scale: Mechanistic Principles for Converting Brownian Motion into Directed Rotation
AnnotationDisertační práce bude zaměřena na mechanistické principy tzv. photogearingu na molekulární úrovni, tedy na převod světlem řízeného primárního pohybu na mechanicky vázanou sekundární rotaci. Zatímco řada molekulárních systémů vykazuje fotoindukované strukturní změny, pouze omezené množství z nich umožňuje skutečný přenos pohybu analogický makroskopickým ozubeným kolům. Cílem práce je objasnit, jak lze unidirekcionální molekulární motory kombinovat s původně Brownovsky rotujícími jednotkami tak, aby byl jejich pohyb vynuceně korelovaný a směrový. Projekt propojí návrh a syntézu molekul, fotochemická a kinetická měření a detailní mechanistickou analýzu, umožňující rozlišit skutečné mechanické vazby od čistě energetických či allosterických efektů. Výsledky přispějí k formulaci obecných návrhových principů molekulárních fotopřevodů a k hlubšímu porozumění řízení pohybu v umělých molekulárních strojích. Glycine alkoxyamines for New Bioconjugation Methodologies
AnnotationPrávě jsme dokončili přístupy ke glycinovým alkoxyaminům, které jsou velkým příslibem v biokonjugaci. V rámci tohoto projektu bude prozkoumán potenciál těchto nepřírodních derivátů aminokyselin pro přístup k novým peptidovým strukturám. PRMT5/MAT2 inhibitors with potential anticancer properties
AnnotationCílem projektu je navrhnout, syntetizovat a strukturně optimalizovat (studie SAR) potenciální inhibitory enzymů PRMT5/MAT2. Takové inhibitory vykazují protinádorovou aktivitu u rakovin s delecí/inhibicí enzymu MTAP. Biologické vlastnosti připravených látek budou vyhodnoceny ve spolupráci s dalšími vědeckými skupinami. Klíčová slova: PRMT5/MAT2, inhibitory; syntéza; strukturně-aktivitní studie Aerosol interaction with air humidity
AnnotationThe hygroscopicity of aerosol particles is their ability to bind water vapor. This changes their shape, size, and phase behavior. This property affects the ability of particles to become cloud condensation nuclei, their optical properties, global climate change, and human health. The project aims to study the interaction of aerosol particles with air humidity in the laboratory. Aerosol particles composed of substances commonly found in atmospheric aerosol will be generated and their hygroscopicity will be studied using a newly constructed humidification chamber. The size of the prepared dry particles will be measured using an APS aerodynamic particle spectrometer, and these particles will then be fed into a humidification chamber that simulates conditions in the human respiratory tract. The size of the humidified particles under conditions corresponding to the first branchings of the bronchi will again be measured by the APS spectrometer. The experimental results will be compared with model predictions. Required education and skills • Master's degree in chemical engineering, physical chemistry, organic technology, chemical physics, meteorology, environmental sciences, • willingness to do experimental work, learn new things, and work in a team. Intercalation of 2D Materials – Formation of Novel Functional Hybrid Structures
AnnotationThe PhD project will focus on studying the intercalation of organic and inorganic molecules into two-dimensional materials, with particular emphasis on semiconducting and magnetic systems. The research aims to understand intercalation mechanisms, the stability of the resulting hybrid structures, and how the inserted species modify the electrical, magnetic, and optical properties of the host materials. The work will include in-situ experiments enabling real-time monitoring of the intercalation process, as well as controlled doping strategies, layer-by-layer property tuning, and targeted modification of functional parameters for applications in electronics, spintronics, and sensing technologies. The expected outcome is the development of new functional 2D hybrid materials with unique properties arising from interactions between the host lattice and the intercalated molecules. Catalytic Synthesis of Bioactive Atropisomers by Aromatic Substitution
AnnotationNaše skupina nedávno vyvinula metodu nukleofilní aromatické substituce pro syntézu léčivých atropizomerů, chirálních konformačních izomerů vznikajících omezenou rotací jednoduché vazby. V této souvislosti jsme objevili fluoridem katalyzovanou reakci, která je mimořádně účinná. V této doktorské práci budeme dále zkoumat tuto metodu pro syntézu atropizomerů a dalších bioaktivních sloučenin. Primárním cílem je pokrok v oblasti katalytické organické syntézy. Ve spolupráci budeme hodnotit biologickou aktivitu jedinečných molekul syntetizovaných v průběhu projektu. Combined Thermodynamic and Structural Study of Polymer Systems Utilizing In-Situ VT-XRD.
AnnotationCombined Thermodynamic and Structural Study of Polymer Systems Utilizing In-Situ VT-XRD. Luminescent molybdenum clusters for radiodynamic therapy under hypoxic conditions
AnnotationOur work involves the synthesis of Mo6 clusters along with studies of their stability, luminescence, and biological activity. While these clusters traditionally generate singlet oxygen upon activation by visible light,we have recently demonstrated that they can also be efficiently excited by X-rays. Our most recent results in radiodynamic therapy (RDT) show that Mo6 clusters can act as effective radiosensitizing agents capable of producing cytotoxic species in deep tumor tissues with reduced oxygen levels. Consequently, these clusters represent a valuable platform for the development of next-generation therapeutics aimed at enhancing cancer radiotherapy. Microscopy of magnetic layered materials
AnnotationThe dissertation thesis focuses on the synthesis, controlled intercalation, and comprehensive characterization of layered magnetic two-dimensional materials. The aim is to elucidate how intercalated atoms and molecules influence magnetic ordering, interlayer coupling, and the resulting transport properties of these systems. The research will include the growth of high-quality crystals, exfoliation into atomically thin layers, and the investigation of magnetic phases, domain structures, coercive fields, and spin-switching mechanisms. The project will also address key transport phenomena such as the anomalous Hall effect, magnetoresistance, and spin-dependent transport, with an emphasis on correlating structural modifications induced by intercalation with magnetic and electronic responses. Magnetic Lorentz TEM microscopy, along with other advanced transmission electron microscopy techniques, will be carried out in collaboration with Forschungszentrum Jülich within the ER-C-1 center for magnetic high-resolution TEM. This combined approach of material synthesis, intercalation engineering, and state-of-the-art characterization will enable a deeper understanding of magnetism in two-dimensional systems and support their potential application in spintronic and quantum technologies. Multifunctional Molecular Spin Switches
AnnotationSwitchable molecular systems are promising candidates for sensors, data storage, and other stimuli-responsive technologies. Among them, a special class of transition-metal complexes with 3d⁴-3d⁷ electronic configurations, known as spin-crossover (SCO) compounds, can reversibly switch between low-spin (LS) and high-spin (HS) states. This project aims to design and synthesise new multifunctional spin-crossover complexes by strategic ligand design to introduce chirality and luminescence properties, enabling the study of synergistic effects between spin-state switching and the development of multifunctional, multi-responsive switchable molecular materials. The ligand design will be tuned with substituents to develop and establish clear structure-function correlations and achieve predictable tuning of spin-state behaviour. The project will involve structural characterization (single-crystal and powder XRD, and Mössbauer spectroscopy), standard spectroscopic techniques (NMR, UV-Vis, vibrational spectroscopy, etc.), magnetic characterization (SQUID magnetometry), and possibly analysis of other physical properties. MXenes and Their Chemical Modification for High-Performance Supercapacitors – Synthesis, Structural Engineering, and Electrochemical Evaluation
AnnotationThis PhD project will focus on the synthesis, functional modification, and application of MXene materials as advanced electrode components for high-performance supercapacitors. MXenes (e.g., Ti₃C₂Tₓ, V₂CTₓ, Mo₂CTₓ) represent a unique class of conductive 2D carbides and nitrides with high surface area, excellent electrical conductivity, and tunable surface chemistry, making them highly promising candidates for electrochemical energy storage. The research will involve the preparation of high-quality MXenes through optimized selective etching and delamination routes, followed by controlled surface engineering—including tuning of termination groups (–O, –OH, –F, –Cl, –S), heteroatom doping, and fabrication of composites with conductive polymers, carbon nanostructures, or other 2D materials. These modifications aim to enhance ion transport, improve pseudocapacitive behavior, increase stability, and boost overall energy density. Advanced electrochemical characterization (CV, GCD, EIS) will be used to evaluate capacitance, charge–discharge kinetics, energy and power densities, and long-term cycling stability. Special emphasis will be placed on correlating structural features—such as interlayer spacing, ion intercalation behavior, and surface termination chemistry—with electrochemical performance. The ultimate goal is to develop and optimize MXene-based electrodes and hybrid systems for next-generation supercapacitors with high power output, excellent stability, and extended operational lifetime. Cerium nanooxides for environmental and bio-applications
AnnotationPráce se zaměřuje na přípravu nanostrukturních oxidů ceru různými především "wet chemical" metodami a jejich využití v environmenálních a bio-aplikacích. Výjimečné povrchové redoxní vlastnosti CeO2 nanostruktur umožňují reaktivní adsorpci/katalytický rozklad nebezpečných polutantů (jako jsou pesticidy nebo léčiva ve vodách), ale i např. bojových chemických látek. Kromě toho nanočástice CeO2 vykazují neobyčejné pseudo-enzymatické vlastnosti a mohou tak napodobovat enzymy v živých organizmech což by mohlo vést k rozvojí umělých enzymů tzv. nanozymů. Design and synthesis of MTAN inhibitors
Annotation5?-Methylthioadenosinová nukleosidáza (MTAN) je uznávaným cílem pro vývoj potenciálních antibakteriálních látek. Inhibitory MTAN proto mohou mít uplatnění v léčbě bakteriálních infekcí. Cílem projektu je návrh, syntéza a strukturní optimalizace (studie vztahů struktury a aktivity, SAR) inhibitorů MTAN. Biologické vlastnosti připravených sloučenin budou hodnoceny ve spolupráci s dalšími výzkumnými skupinami. Designing new MXene architectures: carbon-source engineering for tunable structure and performance
AnnotationThis PhD project, fully funded by the GACR Junior Star grant, focuses on the controlled synthesis and optimisation of MAX phases and their transformation into MXenes, with an emphasis on tailoring morphology using diverse carbon sources. The research will investigate how different carbon allotropes influence MAX phase formation, structural evolution, and the resulting MXene architecture. By systematically tuning the carbon environment during synthesis, the project aims to synthesise MXenes with engineered morphologies, including tubular, porous, and other emerging structures, and to understand how these structural variations affect surface chemistry, defect distribution, and overall functional properties. This project offers an exciting opportunity to expand both the structural and functional diversity of the MXene family through carbon-guided design. Key benefits: - Hands-on training in material synthesis (solid-state reactions, molten salts, etching). - Experience in structural, morphological, and surface characterisation (SEM, TEM, EDS, XRD, Raman spectroscopy, AFM, XPS). - Understanding of structure–property–performance relationships in MXenes and their impact on functional performance in energy applications - Work within an international and interdisciplinary environment. - Participation in international conferences, workshops, and training schools. - Collaboration abroad with research partners. Non-linear dynamics of polymer solutions
AnnotationNon-linear reactions dynamics, such as rhythmic reaction patterns, are essential for regulating cellular functions in spatially and temporally controlled manner. The underlying reaction schemes are not limited to small molecules but oftentimes involve larger assemblies of biomacromolecules. Polymer solutions therefore become minimally complex model systems to mimic aspects of the biological paradigm. In this thesis, conditions for complex solution-phase behavior (oscillations, waves) of polymer molecules and their assemblies will be studied by kinetic simulations using the PREDICI® software package. A systematic parameter analysis in terms of rate coefficients will be performed, with the goal to develop predictive capability for designing experiments in which polymer solutions display predetermined complex reaction dynamics. Novel types of substitutions at boron and carbon atoms in carboranes and metallacarboranes directed to non-taditional drugs
AnnotationAim of this topic is design and synthesis of novel structural blocks that can be incorporated to design of non-traditional drugs. Attention will be given to stereochemistry of substitution on cluster molecules. New ways to influence the conformational mobility of higher calixarenes and their analogues
AnnotationThe work is focused on studying the possibilities of immobilizing or influencing the conformational behavior of larger calixarenes with five or more phenolic subunits, or their analogues. While common methods of fixing conformers in calix[4]arene chemistry consist in alkylation of the lower rim, these methods do not work for higher calixarenes. The aim of the work is to achieve influencing the conformational behavior by rigidifying the upper rim, through bridging neighboring aromatic groups. The prepared derivatives will be further studied as potential receptors for complexation of selected species. Novel 2D materials for electronic applications
AnnotationThe PhD project focuses on an in-depth investigation of doping strategies in 2D transition-metal dichalcogenides (TMDs) for advanced semiconductor applications, with the aim of achieving materials with well-controlled n-type and p-type conductivity. The research will include optimization of growth conditions and synthesis of high-quality bulk crystals, exfoliation into atomically thin layers, and comprehensive structural, chemical, and electrical characterization of the resulting materials. The work will further involve the fabrication and study of both vertical and planar heterostructures, as well as the development of simple electronic and optoelectronic devices such as photodetectors, sensors, and transistors based on 2D materials. The expected outcome is a fundamental understanding of doping mechanisms in TMDs and their impact on device performance. P-Chiral Phosphines as Asymmetric Organocatalysts
AnnotationNedávno jsme objevili nové architektury P-chirálních ligandů, které byly úspěšně použity jako ligandy v asymetrické katalýze zlata. Obecně jsou fosfiny zároveň užitečnými organokatalyzátory v řadě reakcí. V rámci tohoto projektu bude prozkoumán potenciál našich P-chirálních fosfinů v asymetrické organokatalýze, jako jsou cykloadice, Michaelovy adice, allylové substituce nebo umpolungové reakce. Advanced Functional Polyelectrolyte Films for Antibacterial Applications
AnnotationAntibacterial surfaces are increasingly important for reducing microbial contamination and infection risks in healthcare, food processing, and related industries. With the growing challenge of antimicrobial resistance and persistent surface contamination, there is a strong demand for durable, biocompatible, and environmentally safe antibacterial coatings. Current technologies include passive surfaces that prevent adhesion and active surfaces that kill microbes on contact, though achieving long-lasting, biocompatible, and environmentally safe performance remains a challenge. This PhD project focuses on the development of advanced polycation-based polyelectrolyte antibacterial surfaces using the layer-by-layer (LbL) assembly technique, which enables precise control over film thickness, composition, and functionality. The project will investigate various types of positive charges in polycation layers and their influence on film structure, stability, and antibacterial performance. In addition, the integration of biologically active agents such as enzymes and antimicrobial peptides into LbL films will be explore to create the coatings with long-term, synergistic anti-adhesive and active antibacterial functionality. Polyelectrolyte polymer particles for delivery of pro-angiogenic growth factors to support vascularization of polymer scaffolds in bioapplications.
AnnotationIn tissue engineering, vascularization of polymer scaffolds developed for tissue replacement is crucial for their functionality in the recipient body. Direct administration of free pro-angiogenic proteins (e.g., VEGF or FGF-2) often fails to produce effective results. Polymer-based delivery systems, such as nano- and microparticles, enabling controlled and localized release of growth factors, are therefore intensively studied. The PhD project aims to develop polyelectrolyte nano- and microparticles based on charge-shifting poly(dimethylaminoethyl acrylate) (PDMAEA) polycations for the controlled growth factor delivery. The gradual loss of charge on PDMAEA enables controlled particle degradation, sustained release of growth factors, and reduced toxicity, making these systems attractive for biomedical applications. The doctoral research will focus on i) the synthesis of PDMAEA-based block copolymers via RAFT polymerization to tune the particle charge density and corona composition, ii) the preparation of polyelectrolyte particles and characterization of their physicochemical properties (DLS, zeta potential measurements, IR spectroscopy, ITC, TEM), iii) investigation of protein loading and release behavior using ELISA, and iv) the evaluation of particle biocompatibility and protein bioactivity in collaboration with biologists. The interdisciplinary topic focuses on polymer chemistry and biomedical applications and is suitable for graduates of chemical disciplines such as macromolecular chemistry, physical chemistry, biochemistry, etc. Proton conductive phopshonate metal-organic frameworks
AnnotationThe constantly increasing world consumption of energy and the connected environmental problems require the development of new ecological energy sources, which includes a wider utilization of fuel cells and batteries. Proton-exchange membranes are an important part of the devices that separates the space of electrode half-cell reactions. Up to now, proton-exchange membranes are made of mainly conductive polymers which have several drawbacks; high manufacturing price, permeability for some fuels or amorphous character, which does not allow deeper understanding of the transport mechanism. Metal-organic frameworks (MOFs) are crystalline porous coordination polymers composed of metallic nodes interconnected by two- or multidentate organic ligands. The crystalline character of MOFs, the presence of pores, the possibility of rational design of the structures and tuning psysicochemical properties of the pores make MOFs suitable candidates for proton conductive materials. The aim of the work is preparation of new MOFs based on N-heterocyclic phosphonate building blocks trying to maximize their proton conductivity. By introducing phosphonate or phosphinate functional groups onto various N-heterocyclic molecules (bipyridine, pyrazine, imidazole), new ligands will be synthetized, from which new coordination polymers will be prepared and the proton conductivity of the resulting materials will be studied. Synthesis and investigation of azadienes for use in bioorthogonal reactions
AnnotationThe project aims to design and synthesize diverse heterodienes, such as tetrazines, and triazium salts, and to study their reactivity with unactivated and strained dienophiles. The effect of different substituents on reaction kinetics and the compounds' potential for fluorogenic properties will be examined. The most promising candidates will be tested on model biological systems, including proteins (or other biomolecules) and cell cultures. Synthesis of compounds modulating the dynamics of the actin cytoskeleton
AnnotationThe dynamics of the actin cytoskeleton play a key role in cell motility, and influencing this process is crucial for the development of compounds with migrastatic activity. The aim of this work is to design and prepare compounds that will affect actin polymerization based on direct interaction with actin and/or regulatory proteins involved in actin polymerization. Rational design of compounds will be used, as well as a classical approach to studying the SAR. Recycling of polyisocyanurate foams
AnnotationThe plastic waste treatment and a sustainable use of synthetic polymers is one of the major environmental challenges of the 21st century. Polyisocyanurate (PIR) foams are highly rigid foams primarily used for thermal insulation in construction, refrigeration, and other industries. They are produced by reacting polyols (which are typically derived from petroleum-based products) with isocyanates, resulting in a foam that has excellent insulating properties and resistance to fire and heat. PIR foams are chemically similar to polyurethane foams, but they have higher degree of isocyanurate content, which enhances their thermal stability and fire resistance. Recycling PIR foams is therefore challenging because their covalent structure is highly crosslinked and contains hydrolytically highly resistant structures that do not easily undergo chemical depolymerization. The aim of the PhD topic is to study the degradation behavior of PIR foams with the aim of finding a suitable method for their chemical recycling (solvolysis). The PhD candidates should have good communication skills in English (both in speaking and writing), should be able to work both in a team and independently. Active participation on foreign internships, trainings and scientific conferences is expected. Rheology and processing of particle filled polymer melts
AnnotationPolymerní kompozity jsou materiály s vysokým aplikačním potenciálem pro použití v pokročilých technologiích. Téma se zabývá řízením vlastností mezifází polymer-plnivo pomocí povrchové modifikace částic plniva a jeho vlivem na reologické vlastnosti kompozitů se zvláštním důrazem na výskyt tokových nestabilit (žraločí kůže, lom taveniny atd.), které omezují zpracovatelské okno polymerních materiálů. Přestože reologické jevy vyvolané přítomností plniva jsou v literatuře popsány, jejich podstata a vysvětlení je často stále nejasná. Systematická studie vlivu velikosti částic, jejich koncentrace a povrchové modifikace na elastické vlastnosti polymerních tavenin a vznik tokových nestabilit bude základem této doktorské práce. Práce je převážně experimentální s použitím technik oscilační a kapilární reologie. Struktura kompozitů bude zkoumána zejména metodami elektronové mikroskopie a termické analýzy. Self-healing and recyclable polymer networks prepared from renewable resources
AnnotationThe aim of this PhD topic is to prepare and characterize polymer materials based on renewable raw materials (carboxylic acids, vanillin derivatives, furan compounds, etc.). The prepared materials will be dynamically crosslinked through reversible covalent bonds and non-covalent interactions (hydrogen bonding, metal-ligand coordination bonds, complex formation or electrostatic/ionic interactions), which will give the material self-healing and recyclable properties. As part of the doctoral project, a student internship of several months at a foreign collaborating institution (Cracow University of Technology, Poland) is planned. Applicants should have good communication skills in English (spoken and written), and should be able to work in a team and independently. Active participation in foreign internships, trainings and scientific conferences is expected. Self-assembled films of 2D materials
Annotation2D materiály, jako je grafen, vykazují planární krystalické nanostruktury s vynikajícími transportními a mechanickými vlastnostmi. Tyto vlastnosti jsou však silně závislé na molekulární struktuře krystalů a často jsou omezeny odporovostí na jejich okrajových spojích. Vysoce kvalitní okrajové kontakty jsou obvykle dosaženy pomocí depozice z chemické páry (CVD), což omezuje škálovatelnost těchto materiálů ve velkých foliích a objemových 3D strukturách. Cílem této dizertační práce je řešit toto omezení využitím nových metod pro hydrolyzování okrajů 2D materiálů a umožnění jejich samosestavení do 3D struktur. Okrajové spoje samosestavených 2D vrstev jsou bohaté na defekty, radikály a kyslík v omezeném prostoru, čímž vytvářejí intrinsické nanoreaktory. Tyto nanoreaktory budou použity k in-situ syntéze kovových nanočástic, které mají za cíl modulovat odpor okrajových spojů a zlepšit celkový výkon materiálu. Selection and optimization of modified XNA aptamers
AnnotationTématem disertace bude enzymová syntéza hypermodifikovaných xeno-nukleových kyselin a jejich využití v selekci aptamerů. Bude nutno vyvinout enzymovou syntézu modifikovaných XNA knihoven, selekci vazebných sekvencí, reverzní transkripci do DNA a sekvenaci. Cílem bude vývoj stabilních aptamerů vážících cílové molekuly (biomarkery, proteiny apod.). Low-valent carbon compounds as triplet luminophores for OLED applications and photocatalysis
AnnotationNedávný objev unikátních fotofyzikálních vlastností sloučenin nízkovalentního uhlíku[https://doi.org/10.26434/chemrxiv-2025-4vvdm-v2] otevírá cestu k moderním luminoforům výhradně na bázi lehkých prvků, které mají potenciál nahradit, případně doplnit zavedené luminiscenční sloučeniny těžkých kovů. Navrhované PhD téma kombinuje syntézní část a pokročilá spektroskopická měření s primárním cílem definovat vztahy mezi strukturou a luminiscenčními vlastnostmi jako jsou populace tripletových stavů a jejich doba života, vlnová délka emitovaného záření či energetická separace relevantních excitovaných stavů. Cílové luminofory s optimalizovanými vlastnostmi budou dále testovány jako fotokatalyzátory (především v rámci procesů využívající přenos energie triplet-triplet ) a jako zářiče pro elektroluminiscenční OLED zařízení. Stable Nitrogen-Heterocyclic Radicals for the Synthesis of Calcium Ion Channel Inhibitors
AnnotationÚčinná a univerzální syntéza struktur bohatých na dusík vyžaduje neustálý vývoj, vzhledem k jejich významu pro medicínskou chemii a chemickou biologii. V tomto projektu zkoumáme syntetickou využitelnost stabilních N-heterocyklických radikálů s cílem objevit nový chemický prostor. Farmakologický profil syntetizovaných molekul bude hodnocen pomocí patch-clamp elektrofyziologie vápníkových iontových kanálů s cílem vyvinout nové molekuly s analgetickými vlastnostmi. Nanoparticles for photoacoustic imagining studied by the photoacoustic and SERS effect
AnnotationThis PhD project focuses on studying one-pot–modified gold nanoparticles designed for advanced biomedical imaging. The goal is to characterize their plasmonic and surface properties and evaluate their suitability for near-infrared photoacoustic imaging and complementary SERS imaging that provides molecularly specific information. The project involves multimodal analysis of the prepared Au nanoparticles (photoacoustics, IR, Raman, SERS, UV–Vis, TEM, DLS) and investigation of the relationships between surface modification, optical response, and their potential applicability in biomedical diagnostics. Synthesis and Chiroptical Properties of Helicene-Derived Luminophores
AnnotationCílem projektu je příprava nových helikálních TADF a excimerových luminoforů odvozených od helicenů a studovat jejich chiroptické vlastnosti v roztoku a tenkých vrstvách (zejména cirkulárně polarizovanou luminiscenci) za účelem identifikace vhodných materiálů pro budoucí konstrukci CP-OLED. Synthesis of targeted kinase degraders as experimental therapeutics
AnnotationCílem práce bude syntetizovat PROTACy pro několik kináz, které jsou validovanými targety v onkologii a poruchách CNS. Zaměří se na optimalizaci linkerů, výběr ligandů ligáz a specificitu pro cílovou kinázu. Jako výchozí bod poslouží naše nedávno vyvinuté vysoce selektivní nízkomolekulární heterocyklické inhibitory kinas. Synthesis of functionalized polymers and polymer membranes for electrochemical devices
AnnotationIon-exchange polymer membranes are widely used in laboratory and industrial applications. Major applications include electrochemical desalination of seawater and brackish water, wastewater treatment, separation of mixtures in the production of industrial chemicals and pharmaceuticals, separation of electrolytes from non-electrolytes in electrochemical devices such as electrolyzers, fuel cells and batteries. Recently, their use in hydrogen management and storage of excess electricity from renewable sources has become increasingly important. The use of so-called green hydrogen produced in electrolyzers is one of the ways in the transition to carbon-free energy. The topic includes the synthesis of polymers and polymer membranes bearing functional groups for a specific purpose. For example, sulfo and phosphono groups for cation-exchange or quaternary ammonium groups for anione-exchange materials. In addition, these polymers are useful for electrode design, as catalyst supports and for other applications. Preparative organic chemistry and polymerization reaction methods are commonly applied. Our department is flexible enough to give the potential candidate enough room to apply his or her ingenuity. Synthesis of Glycomimetic Organometallic Inhibitors of Galectins
AnnotationGalectins are proteins characterized by affinity to some galactosides and sequence homology. Their interactions with oligosaccharides are involved in many fundamental biological events. Inhibition of these interactions by synthetic analogs of endogenous saccharide agonists (glycomimetics) is of principal significance for their study and for drug development. The main goal of this PhD project is the synthesis and evaluation of hybrid glycomimetic galectin inhibitors based on the combination of carbohydrate and organometallic structural motifs. The incorporation of an organometallic moiety into the structure of a glycomimetic inhibitor can not only result in higher affinity or selectivity of inhibition, but also allow the study of interactions with galectins by electrochemical methods. The presence of the transition metal in the inhibitor molecule also expands the possibilities of its detection in cells and tissues. Required education and skills •Master degree in chemistry. •The willingness to acquire and apply advanced methods of organic synthesis. Synthesis of chiral carboranes and metallacarboranes, their separation and interactions with organic systms
AnnotationChemie chirálních klastrových sloučeniny boru patří dosud k velmi málo prostudovaným oblastem, ačkoliv jejich axiální či helikální chiralita je podobná jako u některých typů organických látek (BINOL) či ansa-substituted metallocenů. Téma se týká připravy opticky aktivních klastrových sloučenin, separace ennantiomerů a využití látek v medicíně. Synthesis of Mono- and Multivalent Inhibitors of Tandem Galectins
AnnotationGalectins are a class of lectins (carbohydrate-binding proteins other than enzymes and antibodies) characterized by affinity to galactosides and sequence homology. So-called tandem galectins comprise two related but non-identical carbohydrate-binding domains (CRD) with partially different substrate specificities. Inhibition of tandem galectins by synthetic analogs of saccharides (glycomimetics) is of great importance in both fundamental research and drug development. The attachment of monovalent domain-specific inhibitors to suitable carriers will result in multivalent inhibitors that can inhibit both domains within the tandem galectin simultaneously and very effectively, if the right topology is achieved. The main goal of this PhD project is the synthesis and evaluation of glycomimetic inhibitors of individual domains and the verification of the hypothesis that an appropriate spatial arrangement of domain-specific inhibitors on a multivalent carrier can lead to high affinity inhibitors of tandem galectins due to a multivalent effect. Required education and skills •Master degree in chemistry. •The willingness to learn and apply advanced methods of organic synthesis. Syntéza nanokompozitů na bázi biopolymerů pro odstranění farmakologických kontaminantů: od syntézy polymerů k environmentálním aplikacím
AnnotationReleasing and accumulating contaminants, especially residues from pharmaceutical products, pose health risks to humans and have a negative and significant impact on the environment. This research focuses on the development of innovative nanocomposites derived from biomass-based monomers and biopolymers for the removal of environmental contaminants. The relationship between the structure and properties of materials for contaminant sorption is still not fully understood, which limits their effectiveness. The scope of this work will first involve the synthesis and comprehensive structural characterization of the prepared nanocomposites, including porosity, stability, mechanical and thermal properties, to explain their efficiency in terms of macromolecular structure and the presence of active sites. The second research objective will be the evaluation of nanocomposites in terms of their sorption efficiency. Sorption kinetics will be studied to identify the mechanism and rate of the sorption process. The third part of the research will focus on the biodegradation of the nanocomposites after sorption in bioreactors using effective microbial cultures (such as activated sludge). The efficiency of pollutant biodegradation within the nanocomposites will be monitored, followed by the biodegradation of the nanocomposite materials themselves. During the biodegradation process, the degradation mechanism and potential degradation products will be observed and analyzed using selected analytical techniques. This project offers an alternative to conventional methods, aiming to minimize environmental impacts and improve the efficiency of environmental technologies. Synthesis of polymer materials and polymer membranes for separation processes
AnnotationPolymer membranes are widely used in separation processes due to their versatility, efficiency, and cost-effectiveness. These membranes are designed to selectively allow certain molecules or ions to pass through while blocking others, making them ideal for applications like water filtration, gas separation, and dialysis. Polymer membranes can be tailored for specific separation tasks by adjusting factors such as pore size, chemical composition, and surface properties. Their applications range from purifying drinking water through reverse osmosis to separating gases in industrial processes. With ongoing advancements, polymer membranes continue to play a crucial role in improving the sustainability and performance of various separation technologies. The subject matter encompasses the synthesis of novel polymers and the functionalization of commercially available materials, with a particular focus on their use in the separation of chemical mixtures, including gases and enantiomeric mixtures. Methodologically, the work will encompass polymerization reactions, the introduction of functional groups into polymers, and the utilization of reactions employed in preparative organic synthesis. Our department is sufficiently flexible to allow the prospective candidate the opportunity to exercise their inventiveness. Thin films of multiferoic hexagonal ferrites with magnetoelectric properties
AnnotationTématem disertační práce je studium tenkých vrstev multiferoických hexagonálních feritů s magnetoelektrickým (ME) jevem připravovaných metodami “měkké” chemie ve formě tenkých vrstev metodami depozice z kapalné fáze (CSD). Vybrané hexaferity strukturního typu U, Y a Z, vykazující magnetoelektrické vlastnosti, patří do skupiny intenzivně studovaných multiferoik (https://www.annualreviews.org/doi/abs/10.1146/annurev-conmatphys-020911-125101). Výzkum bude zaměřen na vývoj a optimalizaci CSD syntetických postupů a studium reálné (mikro)struktury (x-ray a neutronová difrakce, elektronová mikroskopie) a jejího vztahu k funkčním (ME) vlastnostem materiálu. Fyzikální část práce zahrnuje stadium elektrických, dielektrických, magnetických a magnetoelektrických vlastností (ve spolupráci jak s domácími, tak i zahraničními fyzikálními laboratořemi). Printed Electronics Based on 2D Materials – Development of Inks, Heterostructures, and Flexible Devices
AnnotationThe PhD project will focus on the development and investigation of printed electronics utilizing two-dimensional materials. The work will involve formulating stable functional inks based on 2D semiconductors, conductors, and dielectrics, optimizing their physicochemical properties, and studying printing processes such as inkjet, aerosol-jet, and screen printing. The research will include the fabrication of multilayer heterostructures, control of the morphology of printed films, and the development of flexible electronic and optoelectronic components, including sensors, photodetectors, transistors, and energy-related devices. Additional emphasis will be placed on the long-term stability of printed structures, interactions between 2D flakes and binders/substrates/dielectrics, and integration into low-cost or wearable platforms. The expected outcome is the creation of high-performance, fully printed 2D-material-based systems with excellent functional properties and mechanical flexibility. Shaping the morphology of MAX Phases and MXenes: the role of carbon allotropes to tailor their energy storage properties
AnnotationThis PhD project, fully funded by a GACR Junior Star grant, aims to explore the synthesis and optimisation of MAX phases and their transformation into MXenes with a focus on shaping their morphology to enhance their energy storage properties. The research will investigate how different carbon allotropes influence the formation of MAX phases and the structural characteristics of their MXene derivatives. By adjusting the carbon source during synthesis, the project will examine how variations in morphology, including tubular and other previously unexplored structures, affect the physical, chemical, and electrochemical behaviour of MXenes. This work will provide valuable insights into controlling surface chemistry and defects, key parameters governing MXene performance in energy storage systems. The project offers an exciting opportunity to contribute to the development and expansion of MXenes with improved properties for next-generation energy storage applications. Key benefits: - Hands-on training in material synthesis (solid-state reactions, molten salts, etching). - Experience in structural, morphological, and surface characterisation (SEM, TEM, EDS, XRD, Raman spectroscopy, AFM, XPS). - Understanding of structure–property–performance relationships in MXenes for electrochemical applications. - Work within an international and interdisciplinary environment. - Participation in international conferences, workshops, and training schools. - Collaboration abroad with research partners. Conformation and Hydrogen Bonding in Fluorinated Oligosaccharides
AnnotationImportant aspects in the design of carbohydrate-based therapeutics and materials are their conformational properties, which are partly determined by intramolecular hydrogen bonds (H-bonds). To achieve the desired properties of these compound classes, regio- and stereoselective introduction of fluorine is used. However, the influence of fluorine on the intramolecular H-bonds in oligosaccharides formed by functional groups vicinal to fluorine has not been investigated. The aim of this project is to investigate this influence and to elucidate the conformation of selected fluorinated oligosaccharides. Fluorinated disaccharides derived from N-acetyllactosamine and fluorinated trisaccharides derived from the Lewis X antigen (LewisX) will be synthesized and used to study inter-residue H-bonds including the non-conventional H-bond, which stabilizes LewisX. A combination of computational approaches and NMR experiments will be used to elucidate the conformational states and to detect and evaluate intramolecular H-bonds. Required education and skills •Master degree in chemistry. •The willingness to learn and apply advanced methods of organic synthesis and structure elucidation. The use of mechanical bond as a protecting group for the synthesis of porous materials
AnnotationPorous crystalline materials are used for the gas separation and storage, catalysis or chemical sensing. Their properties are strongly related to their porosity. However, one of the problems preventing the preparation of highly porous materials is the interpenetration – the interweaving of multiple crystal lattices. The aim of the project is to use the mechanical bond as a protecting group to prevent the interpenetration and, thus, the preparation of highly porous materials. Introduction of phosphorus and nitrogen atoms into aromatic structures
AnnotationMany synthetic strategies attempt to vary the shape and size of the π-conjugated system of aromatic compounds to obtain optimal properties. Recently, an alternative approach has come to the fore, which introduces a heteroatom (phosphorus, nitrogen) into the aromatic backbone, whose specific properties (chiral center on phosphorus, easy change of oxidation state, possibility of derivatization) significantly influence the behavior of the π-framework. This project deals with developing a simple and efficient preparation that introduces phosphorus and nitrogen into aromatic structures. The aim is to apply this approach to synthesizing polyaromatic compounds such as phenacenes, helicenes, or nanographenes containing phosphorus and nitrogen atoms. Required education and skills: •master's degree in organic chemistry, •experimental skill and practical knowledge of organic synthesis, •teamwork ability, •employment contract at ICPF. High-k and Low-k Two-Dimensional Dielectric Materials for Electronic Applications – Synthesis, Characterization, and Integration into Nanoelectronic Devices
AnnotationThis PhD project will focus on the development, investigation, and device-level implementation of two-dimensional dielectric materials with high (high-k) and low (low-k) permittivity, which are essential components for next-generation nanoelectronics. The work will involve the controlled synthesis and exfoliation of novel 2D dielectric systems—including halides, chalcogenides, layered nitrides, and other wide-bandgap insulators—followed by detailed characterization of their structural, chemical, and electrical properties. The research will include measurements of dielectric parameters (permittivity, loss tangent, dielectric breakdown strength), charge transport, and interfacial stability with key 2D semiconductors such as TMDs, graphene, and emerging ferroelectric layers. The candidate will investigate the role of defects, surface chemistry, interfacial states, and the potential for tuning dielectric behavior through doping, intercalation, or heterostructure engineering. An important part of the project will be the integration of high-k and low-k 2D dielectrics into simple electronic test structures, including FET transistors, capacitors, memory elements, and neuromorphic components. This will include the study of leakage currents, hysteresis, reliability, endurance, and overall performance in device-relevant configurations. The expected outcome is the establishment of new 2D dielectric platforms optimized for ultrathin, flexible, and energy-efficient electronic devices of the future. 2D materials for photo-electrochemical decomposition of water
AnnotationThis thesis is focused on the use of 2D nanomaterials based on layered chalcogenides and their composites for photo-electrochemical water splitting. Student will work on tailoring of their properties by doping, surface functionalization and composition optimization in order to reduce overpotential for photocatalytic hydrogen evolution and optimize the response of materials to different wavelengths of light in the visible and ultraviolet region. 3D printing of poly(glycerol sebacate) for tissue engineering applications
AnnotationPoly(glycerol sebacate) (PGS) is a biocompatible, biodegradable polyester with tunable mechanical properties, representing a promising alternative to non-degradable biomaterials—particularly for soft tissue regeneration and other applications requiring flexible elastomeric scaffolds. This PhD project aims to address current challenges in the 3D printing of PGS, which include optimizing the composition and viscosity of printable “inks,” developing efficient cross-linking methods, whether photo-induced or enzyme-mediated, and improving the biocompatibility of highly hydrophobic PGS through 3D printing of blended inks with biopolymers such as collagen. The student will gain experience in various synthesis techniques, 3D printing methods, and material characterization procedures using modern instrumentation (GPC, ¹H and ¹³C NMR, UV/VIS and fluorescence spectroscopy, Cellink BioX 3D printer, electron and optical microscopy, rheological measurements). A background in polymer chemistry, organic chemistry, or biomaterials is an advantage but not a requirement — what matters most is a willingness to learn and explore new areas in these fields. |
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Updated: 20.1.2022 16:26, Author: Jan Kříž